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In this study, healthy human subjects (18-35 yrs) are be randomised to consume 1200 mg ibuprofen or 75 mg acetylsalicylic acid daily during a training period of 8 weeks. During these weeks, subjects perform 2-3 supervised strength training sessions (knee extensions). Before and after training, muscle volume is measured by MRI, and muscle strength is assessed by isokinetic and isoinertial ergometers. Muscle biopsies are obtained from m. vastus lateralis to study gene and protein expression of markers regulating muscle protein turnover and prostaglandin synthesis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ibuprofen | Experimental | Resistance exercise 20 sessions during 8 weeks Daily consumption of 1200 mg ibuprofen (400 mg x 3) during 8 weeks |
|
| Acetylsalicylic acid | Active Comparator | Resistance exercise 20 sessions during 8 weeks Daily consumption of 75 mg acetylsalicylic acid (75 mg x 1) during 8 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ibuprofen | Drug |
| ||
| Acetylsalicylic acid |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Quadriceps muscle volume | Measured through MRI | Baseline and after 8 weeks training |
| Measure | Description | Time Frame |
|---|---|---|
| Change in muscle gene expression | Through quantitative PCR and microarray | Baseline, 4 weeks and after 8 weeks training |
| Change in muscle protein expression | Through Western Blots |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tommy Lundberg, PhD | Karolinska Institutet | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Karolinska Institutet | Stockholm | 14186 | Sweden |
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| ID | Term |
|---|---|
| D007052 | Ibuprofen |
| D001241 | Aspirin |
| ID | Term |
|---|---|
| D010666 | Phenylpropionates |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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|
| Baseline, 4 weeks and after 8 weeks training |
| Change in Quadriceps muscle strength | Measured in strength dynamometers | Baseline and after 8 weeks training |
| D012459 |
| Salicylates |
| D062385 | Hydroxybenzoates |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |