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| ID | Type | Description | Link |
|---|---|---|---|
| KF-01-18904 |
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| Name | Class |
|---|---|
| Lund University | OTHER |
| The Danish Rheumatism Association | OTHER |
| Ministry of the Interior and Health, Denmark | OTHER_GOV |
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The investigators will investigate the effect of glucosamine or ibuprofen combined with 12 weeks of muscle strength-training in patients with knee-osteoarthritis.
The investigators would like to elucidate whether treatment with glucosamine or NSAID interact with the effects of exercise in osteoarthritis patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Glucosamine | Experimental |
| |
| Ibuprofen | Experimental |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| glucosamine sulphate | Drug | Subjects are administered glucosamine-sulphate tablets of 500 mg * 3 daily, while they are performing a strength-training program with both legs (*3 weekly) for 12 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| muscle strength and hypertrophy | We measure before and after 12-weeks strength training. | |
| cartilage biomarkers | We measure before and after 12 weeks strength training |
| Measure | Description | Time Frame |
|---|---|---|
| muscle regeneration and function | We measure before and after 12-weeks strength training. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Susanne G Petersen, MD | Bispebjerg Hospital, Institute of Sports Medicine Copenhagen | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21807137 | Derived | Petersen SG, Beyer N, Hansen M, Holm L, Aagaard P, Mackey AL, Kjaer M. Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients. Arch Phys Med Rehabil. 2011 Aug;92(8):1185-93. doi: 10.1016/j.apmr.2011.03.009. | |
| 19679221 |
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| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D005944 | Glucosamine |
| D007052 | Ibuprofen |
| ID | Term |
|---|---|
| D006595 | Hexosamines |
| D000606 | Amino Sugars |
| D002241 | Carbohydrates |
| D010666 | Phenylpropionates |
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| ibuprofen | Drug | Subjects are administered 600 mg * 2 daily, while they are performing a strength-training program with both legs (*3 weekly) for 12 weeks |
|
|
| placebo | Drug | Subjects are administered placebo tablets, while they are performing a strength-training program (*3 weekly) with both legs for 12 weeks |
|
| Petersen SG, Saxne T, Heinegard D, Hansen M, Holm L, Koskinen S, Stordal C, Christensen H, Aagaard P, Kjaer M. Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training. Osteoarthritis Cartilage. 2010 Jan;18(1):34-40. doi: 10.1016/j.joca.2009.07.004. Epub 2009 Jul 15. |
| D012216 |
| Rheumatic Diseases |
| D001519 | Behavior |
| D000146 |
| Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |