Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis

Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis

The investigators will investigate the effect of glucosamine or ibuprofen combined with 12 weeks of muscle strength-training in patients with knee-osteoarthritis.

The investigators would like to elucidate whether treatment with glucosamine or NSAID interact with the effects of exercise in osteoarthritis patients.

Inclusion Criteria:

• Age 50 to 70 years
• Bilateral tibiofemoral osteoarthritis of the knee on x-ray
• American College of Rheumatology (ACR) clinical classification criteria

Exclusion Criteria:

• Severe health problems such as cardiovascular disease, active cancer, diabetes, kidney or liver diseases
• Excess alcohol use (> 21 alcoholic drinks per week)
• Severe overweight (BMI > 35)
• History of injury or operation in the knee, planned knee-joint replacement, other rheumatologic diseases, previous gastric ulcer, allergy to the contents of ibuprofen or glucosamine, regular strength training prior to the inclusion