Vitamin K2 Supplementation and Arterial Stiffness in the Renal Transplant Population (The KING Trial)

Vitamin K2 Supplementation and Effect on Arterial Stiffness Progression in the Renal Transplant Population

This study is a single arm, single center clinical trial that aims to evaluate the effect of 8 weeks of vitamin K2 replacement (360 mcg/day) on the progression of arterial stiffness in stable renal transplant patients.

Inclusion Criteria:

• Functional renal graft
• Stable renal function for at least 3 months prior to enrollment

Exclusion Criteria:

• History of thrombotic events
• Diagnosed coagulopathy
• Cardiovascular event in the past month prior to enrollment
• Current or planned pregnancy
• Lactation
• Soy allergy
• Concomitant or recent (past 6 months) use of supplements that contain vitamin K
• Warfarin treatment
• Known intestinal malabsorption or hypomotility syndromes