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| Name | Class |
|---|---|
| Sir Mortimer B. Davis - Jewish General Hospital | OTHER |
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The purpose of this study is to determine if a program of physical activity, nutritional supplements and relaxation techniques is effective at decreasing post operative complications in frail colorectal cancer patients undergoing resection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Prehabilitation | Experimental | Immediately after randomization and until surgery, patients in this arm will:
|
|
| Rehabilitation | Active Comparator | Patients in this arm will receive the same personalized physical exercise program, nutritional intervention and relaxation techniques as patients in the other arm but to be started after surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Physical Exercise Program | Behavioral | Physical exercises personalized by a kinesiologist consisting of walking or stationary bike and elastic band exercises. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Post operative complications | Comprehensive Complication Index (CCI) | 30 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| 6 Minutes Walk Test Distance | 4 weeks after discharge | |
| Hospital Length of Stay | 3-6 days | |
| Readmission rates |
| Measure | Description | Time Frame |
|---|---|---|
| Cost Effectiveness of treatment | Factoring the cost of the program versus possible savings related to other primary and secondary outcomes | 30 days after hospital discharge |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Franco Carli, MD, MPhil | Professor, Department of Anesthesia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| McGill University Health Center; Montreal General Hospital | Montreal | Quebec | H3G 1A4 | Canada | ||
| Sir Mortimer B. Davis - Jewish General Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37162250 | Derived | Molenaar CJ, van Rooijen SJ, Fokkenrood HJ, Roumen RM, Janssen L, Slooter GD. Prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery. Cochrane Database Syst Rev. 2023 May 10;5(5):CD013259. doi: 10.1002/14651858.CD013259.pub3. | |
| 35588252 |
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| Whey Protein Isolate Powder | Dietary Supplement | Nutritional counselling is given to patients to ensure their daily proteins and energy requirements are met. Whey Protein Isolate Powder (Immunocal) is provided. Immunocal1.5g/kg PO (by mouth) per day separated in 2 daily doses |
|
| Relaxation Techniques | Behavioral | Relaxation techniques consisting of breathing exercises and using a relaxation CD. |
|
| 30 days after discharge |
| Anxiety and Depression | Using the Hospital Anxiety Depression Scale (HADS) | 30 days after discharge |
| Health Related Quality of Life | Using the Short Form Health Survey (SF-36) | 30 days after discharge |
| Montreal |
| Quebec |
| H3T1E2 |
| Canada |
| Molenaar CJ, van Rooijen SJ, Fokkenrood HJ, Roumen RM, Janssen L, Slooter GD. Prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery. Cochrane Database Syst Rev. 2022 May 19;5(5):CD013259. doi: 10.1002/14651858.CD013259.pub2. |
| 31968063 | Derived | Carli F, Bousquet-Dion G, Awasthi R, Elsherbini N, Liberman S, Boutros M, Stein B, Charlebois P, Ghitulescu G, Morin N, Jagoe T, Scheede-Bergdahl C, Minnella EM, Fiore JF Jr. Effect of Multimodal Prehabilitation vs Postoperative Rehabilitation on 30-Day Postoperative Complications for Frail Patients Undergoing Resection of Colorectal Cancer: A Randomized Clinical Trial. JAMA Surg. 2020 Mar 1;155(3):233-242. doi: 10.1001/jamasurg.2019.5474. |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D012064 | Relaxation Therapy |
| ID | Term |
|---|---|
| D026441 | Mind-Body Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D001521 | Behavior Therapy |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |
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