Topical negative pressure therapy with instillation of saline solution (6 times daily).

During the instillation of saline solution, aspiration is stopped for 10-15 minutes and subsequently the device is programmed to exert a sub atmospheric pressure in aspiration of at least 50 mmHg up to a maximum of 200 mmHg.

The change of dressing is carried out on the first day after the application of the device, and thereafter, as needed (approximately every 3 or 4 days).

Topical negative pressure therapy with instillation of Amukine Med 0,05% (6 times daily).

During the instillation of Amukine Med 0,05%, aspiration is stopped for 10-15 minutes and subsequently the device is programmed to exert a sub atmospheric pressure in aspiration of at least 50 mmHg up to a maximum of 200 mmHg.

The change of dressing is carried out on the first day after the application of the device, and thereafter, as needed (approximately every 3 or 4 days).

Topical negative pressure therapy (without instillation). The device is programmed to exert a sub atmospheric pressure in aspiration of at least 50 mmHg up to a maximum of 200 mmHg.

The change of dressing is carried out on the first day after the application of the device, and thereafter, as needed (approximately every 3 or 4 days).

frequency of wound without clinical infection

number of days to absence clinical infection

number of days to wounds treatment

number of days to wounds closure