Study Evaluating Novel Biomarkers of AKI (Acute Kidney Injury) in Post-operative Patients

A PILOT Study Evaluating Novel Biomarkers of AKI in Post-operative Patients Undergoing Major Intra-Abdominal Surgery

To validate the use of [TIMP-2]●[IGFBP-7] to predict AKI in patients undergoing major intra abdominal surgery.

A prospective pilot single center study to investigate the potential of [TIMP-2].[IGFBP-7] to predict AKI (Acute Kidney Injury) in patients undergoing major abdominal surgery. The investigators will measure the biomarker once preoperatively and 4-times postoperatively starting at arrival on PACU (post anesthesia care unit).The primary endpoint of this study is the development of AKI stage 2 or 3 within the first 72 postoperative hours.

Inclusion Criteria:

• ≥ 18 years
• High risk patients: General Surgery AKI Risk Index Class III, IV or V
• Major abdominal surgery

Exclusion Criteria:

• Ongoing acute kidney injury Stage 2/3
• History of kidney transplant