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No patients with renal failure
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To validate the use of [TIMP-2]●[IGFBP-7] to predict AKI in patients undergoing major intra abdominal surgery.
A prospective pilot single center study to investigate the potential of [TIMP-2].[IGFBP-7] to predict AKI (Acute Kidney Injury) in patients undergoing major abdominal surgery. The investigators will measure the biomarker once preoperatively and 4-times postoperatively starting at arrival on PACU (post anesthesia care unit).The primary endpoint of this study is the development of AKI stage 2 or 3 within the first 72 postoperative hours.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nephro Check Test | Experimental | We take urine samples and analyse the level of [TIMP-2]●[IGFBP-7] using the NephroCheck Test to diagnose AKI |
|
| serum creatinine measurement | Active Comparator | This is the "Golden standard" to diagnose AKI |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nephro Check Test | Device | Urine sample |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants diagnosed with AKI stage 2 or 3 using the updated rifle "KDIGO" guidelines | 72 Hours |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants who need renal replacement therapy | the need renal replacement therapy wil be evaluated by the nephrologist (acid base disturbances, hypervolemia,...) | 30 Days |
| Measure | Description | Time Frame |
|---|---|---|
| 30-day mortality | 30 days | |
| persistence of renal dysfunction at 30 days | 30 days |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lien Torisaen, MD | Universitair Ziekenhuis Brussel | Principal Investigator |
| Jan Poelaert, Prof.Dr. | Universitair Ziekenhuis Brussel | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitair Ziekenhuis Brussel | Jette | Brussels Capital | 1090 | Belgium |
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| serum creatinine measurement |
| Other |
Blood sample |
|
| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| D006973 | Hypertension |
| D009765 | Obesity |
| D003920 | Diabetes Mellitus |
| D006937 | Hypercholesterolemia |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D006949 | Hyperlipidemias |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
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