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This study examines the clinical relevance of early biomarkers to detect and prevent acute kidney injury. High-risk patients for developing acute kidney injury will be screened at initial presentation (emergency department and intensive care unit) for TIMP2xIGFBP7. In case of elevated readings patients will be randomized in two arms: The control group will be treated with standard care, the intervention group will receive an early nephrologic consultation.
This study examines the impact of an early biomarker-guided intervention on the development of acute kidney injury (AKI). New biomarkers indicate kidney damage in an early stage before developing acute kidney injury according to AKI Kidney Disease Improving Global Outcomes (KDIGO) Definition is detectable. The investigators want to test if it's possible to prevent AKI based on elevated urinary biomarkers. Eligible patients will be randomly assigned to two groups, a control and an intervention Group by an early nephrologic consultation. The interventional group will receive an early preventive nephrologist consultation additionally to standard care.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard care | No Intervention | Patients with elevated biomarkers receive a standard treatment. | |
| Interventional care | Active Comparator | Patients in the interventional population receive an early nephrologist consultation which deliberates with attending doctor on preventing measures according to AKI-KDIGO recommendations. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Early nephrologist consultation | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of AKI in both groups according to AKI KDIGO definition | within 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Need for renal replacement therapy | within 24 hours | |
| Need for renal replacement therapy | within 72 hours | |
| Need for renal replacement therapy |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Martin Kimmel, MD | Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF) | Principal Investigator |
| Mark Dominik Alscher, MD | Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF) | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Robert-Bosch Hospital | Stuttgart | 70376 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29961888 | Derived | Schanz M, Wasser C, Allgaeuer S, Schricker S, Dippon J, Alscher MD, Kimmel M. Urinary [TIMP-2].[IGFBP7]-guided randomized controlled intervention trial to prevent acute kidney injury in the emergency department. Nephrol Dial Transplant. 2019 Nov 1;34(11):1902-1909. doi: 10.1093/ndt/gfy186. |
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| within 30 days |
| Need for renal replacement therapy | within 60 days |
| Length of hospital stay | within 30 days |
| Length of hospital stay | within 60 days |
| Death | within 30 days |
| Death | within 60 days |
| Incidence of AKI in both groups according to AKI KDIGO definition | within 72 hours |
| Severety of AKI in both groups according to AKI KDIGO definition | within 72 hours |
| Incidence of AKI in both groups according to AKI KDIGO definition | within 30 days |
| Severity of AKI in both groups according to AKI KDIGO definition | within 30 days |
| Incidence of AKI in both groups according to AKI KDIGO definition | within 60 days |
| Severity of AKI in both groups according to AKI KDIGO definition | within 60 days |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |