The European Bifurcation Club Left Main Study

The European Bifurcation Club Left Main Study: A Randomised Comparison of Single Versus Dual Stent Implantation for Distal Left Main True Coronary Bifurcation Lesions

The objective of the study is to investigate clinical outcomes following single versus dual stenting strategies for the treatment of true bifurcation distal left main coronary artery lesions.

Inclusion Criteria:

Patients must meet ALL of the inclusion criteria:

• Bifurcation distal left main stem stenosis >50% and

  • Ischaemic symptoms, or
  • Positive non-invasive imaging for ischaemia, or
  • Positive FFR, or
  • LMS IVUS MLA <6mm2

• Left main diameter ≤5.75mm

• True bifurcation lesion type 1,1,1 or 0,1,1

• LAD and Cx diameter both >2.75mm

• Unprotected left main

• Patient ≥18 years old

Exclusion Criteria:

• STEMI <72 hours preceding
• Cardiogenic shock
• Chronic total occlusion of either vessel
• >2 other coronary lesions planned for treatment
• SYNTAX score for planned lesions to be treated >32
• LMS trifurcation if all vessels are ≥2.75mm diameter
• Either bifurcation vessel not suitable for stenting
• Platelet count ≤50 x 10^9/mm3
• Left ventricular ejection fraction ≤20%
• Patient life expectancy less than 12 months
• Participation in another investigational drug or device study
• Patient unable to give informed consent
• Women of child-bearing potential or lactating