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The purpose of the present study was to evaluate the efficacy and safety of subtenon block (SB)anesthesia with dexmedetomidine in combination with bupivacaine versus intravenous dexmedetomidine for postoperative analgesia and emesis control in infants undergoing cataract surgery.
In this prospective, randomized, controlled, double blind trial eighty ASA physical status grade I and II infants (1-12month) undergoing elective cataract surgery in one eye under general anesthesia were studied. Infants were randomly allocated to one of the two groups: subtenon block Group (SB) with dexmedetomidine (n =40) or intravenous dexmedetomidine Group (IV) (n =40). After securing the airway, infants in Group (SB) received SB block with 0.05 mL/kg of 0.5%bupivacaine and 0.5ยต/kg dexmedetomidine mixture, whereas infants in Group (IV) received 1ยต/kg IV dexmedetomidine after induction of anesthesia. Surgery started after 5 min of study drug administration. Postoperative assessment for number of infants requiring rescue analgesia and rescue antiemetics was the primary outcome. CRIES pain scale score , vomiting scale score during4-h study period, incidence of oculocardiac reflex and any surgical difficulty were the Secondary outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| subtenon block Group (SB) | Experimental | received SB block with 0.05 mL/kg of 0.5%bupivacaine and 0.5ยต/kg dexmedetomidine mixture |
|
| intravenous dexmedetomidine Group(IV) | Experimental | received 1ยต/kg IV dexmedetomidine after induction of anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SB dexmedetomidine bupivacaine block | Drug | SB block with 0.05 mL/kg of 0.5%bupivacaine and 0.5ยต/kg dexmedetomidine mixture |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative assessment for number of infants requiring rescue analgesia and rescue antiemetics | by analysis for number of infants withCRIES pain scale score >3 | 4 hours postoperatively |
| postoperative CRIES pain scale score | (0-2 for each parameter) | 4 hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| vomiting scale score | a numeric rank score, where 0= no vomiting 1=vomited once and 2=vomited twice or more | 4 hours postoperative |
| Number of oculocardiac reflex(OCR)events(acute reduction in heart rate of >20%). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| jehan A sayed, MD | Contact | +2 01006253939 | jehan.alloul@yahoo.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assiut Univeristy Hospital | Recruiting | Asyut | 71515 | Egypt |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| D020250 | Postoperative Nausea and Vomiting |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| intravenous dexmedetomidine | Drug | received 1ยต/kg IV dexmedetomidine |
|
by analysis
| intraoperative period |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D009325 | Nausea |
| D012817 | Signs and Symptoms, Digestive |
| D014839 | Vomiting |