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The study will conduct to compare the efficacy of Magnesium sulphate & dexmedetomidine used as adjuvants to bupivacaine in caudal block to provide intra-operative anesthesia as well as post -operative analgesia in pediatric patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group (MG) | Active Comparator | Magnesium sulfate 50 mg add to 1 ml/kg of 0.25%of bupivacaine |
|
| group (D) | Active Comparator | Dexmedetomidine 1 μg/ kg to add to 1ml/kg of 0.25%of bupivacaine |
|
| group (MD) | Active Comparator | 50 mg magnesium sulfate and Dexmedetomidine 1 μg/ kg to add to 1ml/kg of 0.25%of bupivacaine |
|
| group (C) | Active Comparator | 1ml/kg of 0.25%of bupivacaine + 1 ml of normal saline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | Dexmedetomidine 1 μg/ kg |
| |
| Magnesium Sulphate |
| Measure | Description | Time Frame |
|---|---|---|
| Time to first analgesic requirement | The time from end of surgery to the first requirement of postoperative analgesia | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative sedation scores | Level of sedation was recorded throughout the post-anesthesia care unit stay at 15-minute time intervals | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jehan A Sayed, MD | Contact | +2 01006253939 | jehan.alloul@yahoo.com | |
| mohamed amir, MD | Contact | +01005689353 | dr.amir63@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| jehan A Sayed, MD | assistant professor in anesthesia and intensive care department,faculty of medicine,Assiut univeristy,egypt | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Assiut Univeristy Hospital | Recruiting | Asyut | 715715 | Egypt |
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| Drug |
Magnesium Sulphate 50 mg |
|
| Bupivacaine | Drug | 1ml/kg of 0.25%of bupivacaine |
|
| Dexmedetomidine + Magnesium Sulphate + Bupivacaine | Drug | Dexmedetomidine 1 μg/ kg + Magnesium Sulphate 50 mg + 1ml/kg of 0.25%of bupivacaine |
|
| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D008278 | Magnesium Sulfate |
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D017616 | Magnesium Compounds |
| D007287 | Inorganic Chemicals |
| D013431 | Sulfates |
| D013464 | Sulfuric Acids |
| D013456 | Sulfur Acids |
| D013457 | Sulfur Compounds |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
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