Degradation of the Anorexic Hormone Peptide YY

Degradation of the Anorexic Hormone Peptide YY

Peptide YY (PYY) is a gastrointestinal hormone released from the enteroendocrine cell upon food intake. The N-terminal truncated form, PYY3-36, exerts anorexic effects. In this study we want to investigate the kinetics of PYY1-36 and PYY3-36 and to examine whether a C-terminally degraded metabolite, PYY3-34, is formed after infusion of PYY.

Inclusion Criteria:

• Healthy
• Normal BMI (18.5-25kg/m2)

Exclusion Criteria:

• Diabetes Mellitus
• Gastric bypass
• Non-caucasian
• Height changes >3 kg within last two months
• Hemoglobin < 7.6 mmol/l
• Chronic disease
• Smoking
• Regularly use of medicine
• Drug abuse