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The purpose of this study is to investigate the effects of intravenous infusion of two gastrointestinal hormones, PYY3-36 and GLP-1, alone and in combination, on appetite in healthy obese men. The investigators hypothesize that an intravenous infusion of each hormone alone will decrease food intake at a buffet meal and decrease appetite, and that in combination, there will be a greater decrease in food intake and appetite compared to each hormone alone.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| placebo | Placebo Comparator | Study participants will receive a 3 hour IV infusion of saline while fasting. |
|
| PYY3-36 + GLP-1 | Experimental | Study participants will receive a 3 hour IV infusion of (GLP-1 + PYY3-36) while fasting. |
|
| GLP-1 | Active Comparator | Study participants will receive a 3 hour IV infusion of PYY3-36 while fasting. |
|
| PYY3-36 | Active Comparator | Study participants will receive a 3 hour IV infusion of PYY3-36 while fasting. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PYY 3-36 | Biological | 0.8 pmol/kg/min x 3 hours |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Ad libitum energy intake | Immediately following 3h IV infusion |
| Measure | Description | Time Frame |
|---|---|---|
| Energy expenditure (ventilated hood technique). | During 3h IV infusion | |
| Changes in levels of glucose, insulin, C peptide, GIP, leptin, ghrelin, adiponectin, cholecystokinin | Prior to, and 15, 30, 60, 90, 120, 180 mins during IV infusion |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nikolaj T Gregersen, MSc | University of Copenhagen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen | Copenhagen | 1958 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24735885 | Derived | Schmidt JB, Gregersen NT, Pedersen SD, Arentoft JL, Ritz C, Schwartz TW, Holst JJ, Astrup A, Sjodin A. Effects of PYY3-36 and GLP-1 on energy intake, energy expenditure, and appetite in overweight men. Am J Physiol Endocrinol Metab. 2014 Jun 1;306(11):E1248-56. doi: 10.1152/ajpendo.00569.2013. Epub 2014 Apr 15. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| C061785 | peptide YY (3-36) |
| D052216 | Glucagon-Like Peptide 1 |
| ID | Term |
|---|---|
| D004763 | Glucagon-Like Peptides |
| D052336 | Proglucagon |
| D005768 | Gastrointestinal Hormones |
| D006728 | Hormones |
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| GLP-1 |
| Biological |
1.0 pmol/kg/min x 3 hours |
|
| saline infusion | Biological | saline infusion x 3 hours |
|
| Appetite sensation by visual analog scale | Every 30 minutes during 3h IV infusion |
| Gastric emptying (paracetamol) | At time=15, 30, 60, 90, 120, 180 mins during IV infusion |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |