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| ID | Type | Description | Link |
|---|---|---|---|
| 35RC14_9777_EPMR-MA | Other Identifier | Rennes University Hospital |
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Unrandomized, unblinded, monocentric comparative Functional Magnetic Resonance Imaging study.
Prospective functional Magnetic Resonance Imaging study involving a group of participants with Mild Cognitive Impairment due to AD and a control participants group matched for age, education level, verbal Intelligence Quotient as assessed through the French version of the National Adult Reading Test and income group following National Institute of Statistics and Economics Studies classification.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy volunteers | Other | 60 old healthy volunteers (aged 25-75) will undergo an inclusion visit in order to check inclusion and non inclusion criteria. Then will be performed:
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| Patients with early Alzheimer disease | Experimental | 20 patients (aged 60-75) will undergo an inclusion visit in order to check inclusion and non inclusion criteria. Then will be performed:
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| Old healthy volunteers | Experimental | 20 healthy volunteers (aged 60-75) will undergo an inclusion visit in order to check inclusion and non inclusion criteria. Then will be performed:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neuropsychological tests | Other | Scales and tests to evaluate:
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| Measure | Description | Time Frame |
|---|---|---|
| Improvement of recognition memory accuracy measures under the familiarity condition as compared with the novel condition in the AD-MCI group | 3 months | |
| Significant effect of the familiarity vs novelty condition on the pattern of % BOLD signal change in across the brain in the AD-MCI group | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Significant group effect on the pattern of % BOLD signal change in across the brain | 3 months | |
| Predictive validity of the brain % BOLD signal change pattern for participants clinical status (i.e. controls vs. AD-MCI) | 3 months |
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Inclusion Criteria:
Volunteers (pilot phase)
Volunteers (experimental phase)
AD-MCI participants
Exclusion Criteria:
MRI contraindications (all participants)
Claustrophobia
Wearing of any metal implant such as:
Other criteria (all participants)
Other criteria (control participants)
- Global cognitive impairment attested by Mattis Dementia Rating Scale or Mini-Mental State Examination, according to available normative data
Other criteria (AD-MCI participants)
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Universitaire | Rennes | 35033 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34837869 | Result | Jonin PY, Duche Q, Bannier E, Corouge I, Ferre JC, Belliard S, Barillot C, Barbeau EJ. Building memories on prior knowledge: behavioral and fMRI evidence of impairment in early Alzheimer's disease. Neurobiol Aging. 2022 Feb;110:1-12. doi: 10.1016/j.neurobiolaging.2021.10.013. Epub 2021 Oct 29. |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D009483 | Neuropsychological Tests |
| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
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| A cranial MRI | Device |
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| Experimental procedure | Other |
|
| Significant interaction between the kind of familiarity condition (i.e. novel, experimental or pre-experimental) and the estimates of recognition memory processes efficiency (i.e. respective contributions of recollection and familiarity, % correct) | 3 months |
| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D003072 | Cognition Disorders |