Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 2007-27 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of this project is to follow cohort of patients with aMCI in order to establish whether there are distinct subgroups in terms of evolution or aetiology, with distinct memory profiles and profiles of mesiotemporal atrophy and metabolic change
The syndrome of "amnestic Mild Cognitive Impairment" (aMCI) has been introduced for patients with intact activities of daily living, with a memory complaint and objective memory decline on neuropathological assessment, without significative change in other domains of cognition. Follow-up in these patients shows that the memory impairment may remain stable or improve, while it worsens or extends to other cognitive domains in others, indicating prodromal AD.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Other | Subject control |
|
| 2 | Experimental | 40 patients before hand include in a program |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neurological and neuropsychological consultation, MRI | Other | Neurological and neuropsychological consultation, MRI for the month 0, 18 and 36 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pursue the longitudinal study of a troop of subjects presenting an amnestic MCI in 36 months after the initial diagnosis | 36 months | |
| Characterize the clinical evolution of these subjects: escalation with appearance of an insanity (of type Alzheimer's disease or of another type: degenerations fronto-temporal, insanity with body of Lewy), stabilization even improvement. | 36 months | |
| Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict an escalation | 36 months | |
| Identify the neuropsychological markers and of neuroimaging structural and metabolic useful in clinical practice which allow to predict a stabilization or an improvement. | 36 months | |
| Improve the state of the knowledge on the origin of the confusions mnésiques isolated at the persons of fifty and more years old. | 36 months |
| Measure | Description | Time Frame |
|---|---|---|
| Establish diagnostic criteria which allow to improve the sensibility and the specificity of the premature diagnosis of MY. | 36 months | |
| Determine if the ultra-premature diagnosis of MY at a stage where the hurts are still confined in the structures under - hippocampiques is possible. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Matthieu CECCALDI, MD | Assistance Publique des Hopitaux de Marseille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hopital de la Timone- Service de neurologie et de neuropsychologie | Marseille | 13005 | France |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA | Other | Neurological and neuropsychological consultation, MRI, Studies in imaging of drip, DNA, months 0/18/36 |
|
| 36 months |
| Determine the specific character or not of the infringement of the memory of visual recognition in the novice Alzheimer's disease. | 36 months |
| Determine the specific character or not the atrophy and the metabolic modifications of regions under - hippocampiques in the novice Alzheimer's disease. | 36 months |
| Inform the existence of process of functional compensation in the population of aMCI, notably to those who show themselves stable or improve. | 36 months |
| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
| ID | Term |
|---|---|
| D009682 | Magnetic Resonance Spectroscopy |
| D004247 | DNA |
| ID | Term |
|---|---|
| D013057 | Spectrum Analysis |
| D002623 | Chemistry Techniques, Analytical |
| D008919 | Investigative Techniques |
| D009696 | Nucleic Acids |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
Not provided
Not provided