Comparative Study of the Hypoxia Measured in FAZA and F-miso PET/CT Scan in Patients With Non-small Cell Lung Cancer

Comparative Study of the Hypoxia Measured in FAZA and F-miso TEP/CT Scan in Patients With Non-small Cell Lung Cancer at the Time of Diagnosis : Correlation With Immunohistochemistry

The purpose of the study is to compare the intratumoral biodistribution of FAZA and F-miso in patients with non-small cell lung cancer and correlate the results of PET scans with immunohistochemistry.

The aim of the study is to compare the biodistribution of the two tracers specific for hypoxia in patients with non-small cell lung cancer.

Two PET scans will be performed with FAZA and F-Miso tracers. The time between these twi PET scans will be 24 hours.

another 24 hours after the late PET scan, the surgery will be done and a piece of tumor will be collected.

Piece of tumor will be analysed by immunohistochemistry for hypoxia markers.

The results of immunohistochemistry will be correlated with the biodistribution of the two tracers.

Inclusion Criteria:

• Male or female
• More than 18 years old
• Patient with non-small cell lung cancer (histologically proved)
• PS inferior or equal to 1 (good general state)
• Patient must have surgery for their non-small cell lung cancer
• Stage of tumor Superior or equal to 2a without metastasis
• Tumoral fixation with 18-FDG-PET superior to mediastinal background noise
• Written inform consent

Exclusion Criteria:

• Histology other than primitive non-small cell lung cancer
• In situ form at the histological study
• Patient without evaluable target
• No fixation on the pretherapeutic FDG-PET scan
• PS Superior or equal to 2
• neoplastic disease (less than 2 years or progressive)
• Pregnant woman or child-bearing
• Patient Under guardianship or curators