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| Name | Class |
|---|---|
| The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | OTHER |
| Shandong Provincial Hospital | OTHER_GOV |
| Third Affiliated Hospital, Sun Yat-Sen University | OTHER |
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portal vein thrombosis may be a negative prognostic marker of variceal bleeding in liver cirrhosis. Compared with conventional endoscopic and pharmacological therapy, transjugular intrahepatic portosystemic shunt may further improve the outcomes of portal vein thrombosis in liver cirrhosis with variceal bleeding.
Portal vein thrombosis may be a negative prognostic marker of variceal bleeding in liver cirrhosis. Compared with conventional endoscopic and pharmacological therapy, transjugular intrahepatic portosystemic shunt may further improve the outcomes of portal vein thrombosis in liver cirrhosis with variceal bleeding. However, the safety of transjugular intrahepatic portosystemic shunt remains uncertain in patients with portal vein thrombosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TIPS group | Active Comparator | Transjugular intrahepatic portosystemic shunt |
|
| ET & drugs groups | Active Comparator |
|
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transjugular intrahepatic portosystemic shunt | Procedure | Transjugular intrahepatic portosystemic shunt refers to an interventional radiological procedure by placing a stent between portal vein and hepatic vein. No specific device was used in the Interventional field. |
| Measure | Description | Time Frame |
|---|---|---|
| All-cause rebleeding or all-cause death | Cumulative incidence of all-cause rebleeding or all-cause death | 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Portal vein recanalization | Incidence of portal vein recanalization | 3 years |
| Other decompensations of portal hypertension | defined as ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome |
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Inclusion criteria
Exclusion criteria
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guohong Han, MD | Contact | 86-13991969930 | 13991969930@126.com | |
| Yong Lv, MD | Contact | lvyong126@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Guohong Han, MD | Xi'an International Medical Center Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the First Affiliated Hospital, Air Force Medical University | Completed | Xi'an | Shaanxi | 710032 | China | |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20932597 | Background | Han G, Qi X, He C, Yin Z, Wang J, Xia J, Yang Z, Bai M, Meng X, Niu J, Wu K, Fan D. Transjugular intrahepatic portosystemic shunt for portal vein thrombosis with symptomatic portal hypertension in liver cirrhosis. J Hepatol. 2011 Jan;54(1):78-88. doi: 10.1016/j.jhep.2010.06.029. Epub 2010 Aug 27. | |
| 28682164 | Background |
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| Southern Medical University, China | OTHER |
| First Affiliated Hospital of Xinjiang Medical University | OTHER |
| The First Affiliated Hospital of Nanchang University | OTHER |
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| Non-selective beta blockers | Drug | Non-selective beta blockers are the drugs for reducing the portal pressure. |
|
|
| Endoscopic therapy | Procedure | Endoscopic therapy includes the endoscopic variceal band ligation |
|
| Anticoagulation | Drug | Anticoagulation therapy includes heparin and warfarin. |
|
|
| 3 years |
| adverse events of treatment | Incidence of adverse events of treatment | 3 years |
| Quality of life | quality of life assessed by the SF-36 health survey | 3 years |
| Overall survival | Overall survival rate | 3 years |
| Hepatocellular Carcinoma | Incidence of Hepatocellular Carcinoma | 3 years |
| Xi'an International Medical Center Hospital |
| Recruiting |
| Xi'an |
| Shaanxi |
| 710100 |
| China |
|
| Nanfang Hospital Affiliated to Southern Medical Univers | Recruiting | Guangzhou | China |
|
| The Third Affiliated Hospital of Sun Yat-sen University | Recruiting | Guangzhou | China |
|
| Provincial Hospital Affiliated to Shandong University | Recruiting | Jinan | China |
|
| The First Affiliated Hospital of Nanchang University | Recruiting | Nanchang | China |
|
| Affiliated Drum Tower Hospital of Nanjing University Medical School | Recruiting | Nanjing | China |
|
| The First Affiliated Hospital of Xinjiang Medical University | Recruiting | Ürümqi | China |
|
| Lv Y, He C, Wang Z, Guo W, Wang J, Bai W, Zhang L, Wang Q, Liu H, Luo B, Niu J, Li K, Tie J, Yin Z, Fan D, Han G. Association of Nonmalignant Portal Vein Thrombosis and Outcomes after Transjugular Intrahepatic Portosystemic Shunt in Patients with Cirrhosis. Radiology. 2017 Dec;285(3):999-1010. doi: 10.1148/radiol.2017162266. Epub 2017 Jul 5. |
| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D019168 | Portasystemic Shunt, Transjugular Intrahepatic |
| D011433 | Propranolol |
| D014859 | Warfarin |
| ID | Term |
|---|---|
| D011170 | Portasystemic Shunt, Surgical |
| D000714 | Anastomosis, Surgical |
| D013514 | Surgical Procedures, Operative |
| D058017 | Vascular Grafting |
| D014656 | Vascular Surgical Procedures |
| D013504 | Cardiovascular Surgical Procedures |
| D050198 | Phenoxypropanolamines |
| D011412 | Propanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D020005 | Propanols |
| D000588 | Amines |
| D009281 | Naphthalenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D011083 | Polycyclic Compounds |
| D015110 | 4-Hydroxycoumarins |
| D003374 | Coumarins |
| D001578 | Benzopyrans |
| D011714 | Pyrans |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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