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A randomized clinical trial to assess the effectiveness of same-day cervical preparation with oral, buccal or vaginal Misoprostol, given 2-4 hours prior first trimester curettage.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PO Misoprostol | Active Comparator | Cervical preparation with per-os (PO) Misoprostol 400 mcg 2-4 hours prior to curettage |
|
| PV Misoprostol | Active Comparator | Cervical preparation with per-vagina (PV) Misoprostol 400 mcg 2-4 hours prior to curettage |
|
| Buccal Misoprostol | Active Comparator | Cervical preparation with buccal Misoprostol 400 mcg 2-4 hours prior to curettage |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Misoprostol (cytotec) | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Preoperative cervical width in centimeters | • Initial cervical dilatation assessed by performing cervical dilatation , beginning with a number 10 Hegar dilator and subsequently inserting smaller Hegar dilators until the dilator can pass through the internal os without resistance. The largest one to pass will consist the initial cervical width. | intraoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Time required to achieve cervical dilatation | The time in minutes required for dilatation up to a number 10 Hegar | intraoperative |
| Ease of cervical dilatation | The subjective ease of cervical dilatation recorded by the surgeon on a 5-point Likert scale (1-very difficult, 5- very easy |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hadas Ganer Herman, MD | Contact | 972-077-2066960 | hadassganer@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Hadas Ganer Herman, MD | Edith Wolfson Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Edith Wolfson Medical Center | Recruiting | Holon | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34061352 | Derived | Ghosh J, Papadopoulou A, Devall AJ, Jeffery HC, Beeson LE, Do V, Price MJ, Tobias A, Tuncalp O, Lavelanet A, Gulmezoglu AM, Coomarasamy A, Gallos ID. Methods for managing miscarriage: a network meta-analysis. Cochrane Database Syst Rev. 2021 Jun 1;6(6):CD012602. doi: 10.1002/14651858.CD012602.pub2. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 8, 2016 | |
| Reset | Jan 5, 2017 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 8, 2016 | Jan 5, 2017 |
| ID | Term |
|---|---|
| D016595 | Misoprostol |
| ID | Term |
|---|---|
| D011459 | Prostaglandins E, Synthetic |
| D011465 | Prostaglandins, Synthetic |
| D011453 | Prostaglandins |
| D015777 | Eicosanoids |
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| intraoperative |
| Patient preference | Patient acceptability of the administration of medication on a 5-point Likert scale (1-very uncomfortable, 5-very comfortable) | baseline |
| Adverse effects of medication | Self reported misoprostol-associated adverse effects before the procedure (such as nausea, vomiting) | baseline |
| Surgical complications | Complications arising during surgery (perforation, cervical laceration, excess bleeding) | intraoperative |
| D005231 |
| Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |
| D012898 | Autacoids |
| D018836 | Inflammation Mediators |
| D001685 | Biological Factors |