Different Routes of Misoprostol Prior to First Trimester Surgical Abortion

Different Routes of Misoprostol for Same-day Cervical Preparation Prior to First Trimester Surgical Abortion: a Randomized Controlled Trial

A randomized clinical trial to assess the effectiveness of same-day cervical preparation with oral, buccal or vaginal Misoprostol, given 2-4 hours prior first trimester curettage.

Inclusion Criteria:

• Patients admitted for elective first trimester abortion (termination of pregnancy/ missed abortion) at Wolfson Medical Center, gestational age <13+0 weeks
• Written consent supplied

Exclusion Criteria:

• Contraindications to prostaglandin treatment (severe asthma, glaucoma, severe cardiac disease, renal failure)
• Prostaglandin allergy
• Genital infection
• Space-occupying lesion in the endocervical canal
• Prior cervical surgery