Search of Protein Biomarkers in Order to Achieve a Molecular Classification of Gliomas

Search of Protein Biomarkers in Order to Achieve a Molecular Classification of Gliomas

The aim is to classify high grade glioma by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI). In order to provide more specific informations for the diagnosis and the prognosis of high grade glioma.

Main inclusion criteria:

• Patients with grade III or IV glioma newly diagnosed with histological evidence
• Surgical indication
• Tumor tissue available at biobank of Lille
• Men and women aged ≥ 18 years
• Informed Consent signed by the patient or his legal representative.

Main exclusion criteria:

• Antecedents of other cancers except basal cell skin cancer or carcinoma in situ of the uterus cervix
• Previous history of brain radiotherapy
• Anti-tumor systemic treatments (chemotherapy or targeted therapy) prior to surgery of glioma
• Genetic disease that may cause brain tumor, potentially radiation-induced tumor
• History of degenerative neurological disease prior to diagnosis
• contraindication to MRI