Biomarker-based Algorithm for Diagnosis of Glioma

Development of a New Algorithm-based Classification for Glioma

ATRX (X-linked mental retardation and alpha-thalassaemia syndrome protein) loss and pTERT (Telomerase reverse transcriptase) mutation are diagnostic markers of gliomas. However, 4 to 28% of gliomas shows none of these alterations. The aim of this project is to propose a new test able to detect the telomeric status for every glioma. Based on this test and other markers (such as mutation of IDH1 (isocitrate dehydrogenase 1) and IDH2 (isocitrate dehydrogenase 2)), investigators propose an algorithm, able to classify the main subtypes of gliomas (astrocytoma, oligodendroglioma and glioblastoma).

Inclusion Criteria:

• Patient with a diagnosis of glioma (retrospective),
• Patient with available biological material : extracted DNA and/or FFPE tissue and/or frozen sample.
• Samples are not required any more for diagnosis purpose
• Patient with informed consent

Exclusion Criteria:

• Patient with no informed consent
• Patients with no available biological sample