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| Name | Class |
|---|---|
| Centre de Recherche en Nutrition Humaine d'Auvergne | OTHER_GOV |
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Colorectal Cancer is, in non-smokers for both sex, first cause of cancers mortality in Western country.
The main risk factors associated with colorectal cancer depend of lifestyle, and processed meat and red meat could be involved in carcinogenesis by cytotoxic and genotoxic compound linked to lipid peroxidation and nitrosation.
The aim of this study is to study the impact of the daily consumption of beef, processed or not, on lipid peroxidation induced heme iron ; and to study the impact of the daily consumption of ham, processed or not, on the nitrosilation induced heme iron.
24 healthy volunteers will be randomized and will start the study. The study will last 12 weeks for each subject. The first week will be a week of adaptation (or run-in period) to the diet which they will have to follow for the duration of study. During this period, they will collect 3 samples of stools and urine. Then subjects will alternate 4 days of diet either with ham, or with ham and pomegranate extract, or with ham enriched with vitamin E or sirloin steak, marinated sirloin steak or marinated cooked sirloin steak. At least, 3 days will separate every period (wash-out) of nutritional intervention. Urines and stools will be collected last 3 days of every interventional period and also last day of every wash out period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ham | Placebo Comparator | 160g per day during 4 days |
|
| ham + pomegranate extract | Experimental | 160g per day during 4 days |
|
| ham + tocopherol | Experimental | 160g per day during 4 days |
|
| rare sirloin steak | Placebo Comparator | 110g per day during 4 days |
|
| marinated rare sirloin steak | Experimental | 110g per day during 4 days |
|
| marinated cooked sirloin steak | Experimental | 110g per day during 4 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ham | Other | 160g per day during 4 days |
| |
| ham + pomegranate extract |
| Measure | Description | Time Frame |
|---|---|---|
| Fecal marker | TBARS Fecal for red meat pane and NOCs Fecal for ham | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| NOC | Fecal marker for red meat pane | 12 weeks |
| cytotoxic activity of fecal water | Fecal marker for red meat pane | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Fabrice PIERRE, Phd | Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement | Study Chair |
| Noel CANO, Md, Phd | University Hospital, Clermont-Ferrand | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CRNH Auvergne | Clermont-Ferrand | Auvergne | 63009 | France |
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| Other |
160g per day during 4 days |
|
| ham + tocopherol | Other | 160g per day during 4 days |
|
| rare sirloin steak | Other | 110g per day during 4 days |
|
| marinated rare sirloin steak | Other | 110g per day during 4 days |
|
| marinated cooked sirloin steak | Other | 110g per day during 4 days |
|
| DHN-MA | urinary marker for red meat pane | 12 weeks |
| TBARs | Fecal marker for ham | 12 weeks |
| cytotoxic activity of fecal water | Fecal marker for ham | 12 weeks |
| DHN-MA | urinary marker for ham | 12 weeks |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
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| ID | Term |
|---|---|
| C501309 | ATF7IP protein, human |
| D024505 | Tocopherols |
| ID | Term |
|---|---|
| D014810 | Vitamin E |
| D001578 | Benzopyrans |
| D011714 | Pyrans |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
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