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| Name | Class |
|---|---|
| University College Dublin | OTHER |
| Connolly Hospital Blanchardstown | OTHER |
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Acute consumption of dietary nitrate (as beetroot juice) has been shown to improve exercise capacity in athletes, healthy adults and subjects with both peripheral vascular disease or COPD. Many patients with dilated cardiomyopathy have reduced exercise capacity, The investigators hypothesized that acute nitrate consumption might increase incremental shuttle walk test (ISWT) distance in dilated cardiomyopathy subjects compared to a placebo beetroot juice.
Acute consumption of dietary nitrate (as beetroot juice) has been shown to improve exercise capacity in athletes, healthy adults and subjects with both peripheral vascular disease or COPD. Many patients with dilated cardiomyopathy have reduced exercise capacity, The investigators hypothesized that acute nitrate consumption might increase incremental shuttle walk test (ISWT) distance in dilated cardiomyopathy subjects compared to a placebo beetroot juice. This study is a randomized, double-blind placebo-controlled, crossover trial. Resting blood pressure, phlebotomy and ISWT will be performed. Following completion, each subject is randomized to consume beetroot juice or placebo. 3 hours later, the same assessments are repeated by the same people. After a 7d washout, the entire protocol is repeated with the crossover beverage.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nitrate rich beetroot juice | Experimental | Concentrated, beetroot juice is a rich source of dietary nitrate. |
|
| Nitrate depleted placebo beetroot juice | Placebo Comparator | Placebo beetroot juice is identical to active beetroot juice in every way except nitrate content. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary nitrate | Dietary Supplement | 140ml of nitrate rich beetroot juice provides 12.9mmol nitrate and will be on a single occasion by the study subjects. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change between incremental shuttle walk test distance pre and post juice | Day 1 and day 8 |
| Measure | Description | Time Frame |
|---|---|---|
| Clinic blood pressure | Day 1 and day 8 | |
| Plasma nitrate | Day 1 and day 8 | |
| Dyspnoea using self report, validated Borg scale |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jim O 'Neill, MD | Connolly Hospital Blanchardstown | Principal Investigator |
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| ID | Term |
|---|---|
| D009202 | Cardiomyopathies |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| Placebo | Dietary Supplement | 140ml of nitrate depleted beetroot juice provides 0.5mmol nitrate and will be on a single occasion by the study subjects. |
|
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| Day 1 and day 8 |
| Oxygen saturation using pulse oximetry | Day 1 and day 8 |
| Plasma nitrite | Day 1 and day 8 |