In the past few years, studies have evaluated the effect of systemic use of sodium alendronate, especially in the treatment of structural bone defects caused by periodontal diseases. This study evaluated the effects of non-surgical periodontal treatment associated with the topical application of 1% sodium alendronate on clinical and topographical parameters. Chronic periodontitis patients were recruited for the present study and were monitored at 3 and 6 months after baseline examinations. A placebo gel was used as control.

Inclusion Criteria:

• chronic periodontitis
• two contralateral teeth showing periodontal pocket depth ≥ 5mm, clinical attachment loss > 3mm, proximal vertical bone defects, no prosthetic device, without caries lesions, proximal dental contact and lack of premature occlusal contact
• systemically healthy volunteers

Exclusion Criteria:

• need for antibiotic or systemic/local antibiotic use in the previous 3 months
• periodontal treatment in the previous 6 months
• pregnancy or lactation
• immunological disorders or imune suppressive treatments
• diabetes
• smoking
• orthodontic appliances or removable prosthesis
• osteoporosis
• known or suspected allergy to biphosphonates
• systemic use of biphosphonates