Respiratory Mechanics and Metabolic Changes During Low Pressure Laparoscopic Cholecystectomy

The Impact of Deep Versus Moderate Neuromuscular Block on Respiratory System Mechanics and Metabolic Changes During Laparoscopic Cholecystectomy a Double-Blind Randomized Clinical Trial.

The investigators aim to investigate the differences between deep continuous muscle relaxation and moderate blockade during low-pressure (8 mmHg) laparoscopic cholecystectomy in respect to metabolic changes and respiratory mechanics.

Inclusion Criteria:

• more than 18 years
• undergoing elective laparoscopic cholecystectomy

Exclusion Criteria:

• previous surgeries,
• a history of venous or arterial diseases,
• BMI (≥30 kg/m2),
• Allergy to rocuronium.
• Significant liver dysfunction.
• Significant renal dysfunction (S-creatinine > 200 umol/l).
• Neuromuscular disease that might impair neuromuscular blockade
• Pregnant or breastfeeding.
• Indication for rapid sequence induction.
• Inability to informed consent