Effects of Deep Neuromuscular Blockade on Intraoperative Respiratory Mechanics

Effects of Deep Versus Moderate Neuromuscular Blockade on Intraoperative Respiratory Mechanics in Patients Undergoing Laparoscopic Renal Surgery: a Prospective, Randomized, Parallel Design Study

The primary objective of the current study is to compare intraoperative respiratory mechanics in patients receiving laparoscopic renal surgery under deep neuromuscular blockade (dNMB) and under moderate neuromuscular blockade (mNMB). In addition, we will compare intraoperative hemodynamics and postoperative pulmonary function between the two groups.

Inclusion Criteria:

• ASA I or II patients scheduled to undergo laparoscopic renal surgery

Exclusion Criteria:

• BMI ≥35 kg/m2
• Known neuromuscular disease
• History of chronic obstructive pulmonary disease
• Asthma
• Pneumothorax
• Bronchopleural fistula
• Previous lung surgery
• Previous retroperitoneal surgery
• Hemodynamic instability
• History of cardiopulmonary disease
• Renal insufficiency