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All consecutive patients admitted in ILBS from MAY 2015 to DECEMBER 2016.ACLF (Acute on chronic Liver Failure). ACLF will be randomize into
Group 1: MVP (Modest Volume Paracentesis) OF Less than 5 liters with IV albumin at a dose 8 gms/L of ascitic fluid
Group 2: MVP (Modest Volume Paracentesis) of Less than 5 liters without albumin
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Albumin | Experimental | MVP (Modest Volume Paracentesis) of less than 5 litres with intravenous albumin at a dose 8 gms/l of ascitic fluid. |
|
| No Albumin | Active Comparator | MVP (Modest Volume Paracentesis) of less than 5 litres without albumin. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Albumin | Drug | Intravenous albumin 8 gms/L of ascitic fluid |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Total number of patients develop Circulatory Dysfunction because of paracentesis. | 1 Year |
| Measure | Description | Time Frame |
|---|---|---|
| Survival | 28 days | |
| Total number of patients develop hepatorenal Syndrome. | 1 Year | |
| Total number of patients develop hyponatremia. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Liver and Biliary Sciences | New Delhi | National Capital Territory of Delhi | 110070 | India |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31849085 | Derived | Arora V, Vijayaraghavan R, Maiwall R, Sahney A, Thomas SS, Ali R, Jain P, Kumar G, Sarin SK. Paracentesis-Induced Circulatory Dysfunction With Modest-Volume Paracentesis Is Partly Ameliorated by Albumin Infusion in Acute-on-Chronic Liver Failure. Hepatology. 2020 Sep;72(3):1043-1055. doi: 10.1002/hep.31071. Epub 2020 Jul 9. |
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| ID | Term |
|---|---|
| D065290 | Acute-On-Chronic Liver Failure |
| ID | Term |
|---|---|
| D017114 | Liver Failure, Acute |
| D017093 | Liver Failure |
| D048550 | Hepatic Insufficiency |
| D008107 | Liver Diseases |
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| ID | Term |
|---|---|
| D000418 | Albumins |
| ID | Term |
|---|---|
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
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| Ascitic fluid |
| Drug |
|
| 1 Year |
| Changes in aldosterone with volume of ascitic fluid tap | 1 Year |
| Changes in plasma renin activity | 1 year |
| D004066 |
| Digestive System Diseases |