Phase II prospective study or Palliative Radiotherapy of 25 Gy in 5 fractions, Intensity Modulated, for frail patients with incurable head and neck cancer. Comprehensive Quality of life (QLQ-C30, head and neck module, QLQ C15 PAL) and toxicity data (CTCAE v 4.0) collected.

Patients deemed too frail for radical treatment or incurable because of tumour extension, as determined by an experienced tumour board, were eligible for this study of palliative radiotherapy delivered by intensity modulation, 25 Gy in 5 daily fractions over one week. This study was conducted in two academic centers.

Inclusion Criteria:

• Able to give an informed consent
• Able to complete QOL questionnaires
• Deemed incurable by an experienced tumour board or unwilling to receive a radical course of radiation therapy
• Presence of measurable disease
• Biopsy proven squamous or salivary cancer of the head and neck region
• Expected survival of at least 2 months.

Exclusion Criteria:

• Pregnancy
• No previous RT to the neck and no plan to receive concomitant chemotherapy
• Special histology (Lymphoma, small cell cancer, metastasis from a site other than the head and neck region)
• Unavailable for follow-up