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This study is a phase II trial designed to test the feasibility of delivering IMRT to head and neck cancer patients with tumours arising in the midline (oropharynx and hypopharynx), and to assess possible improvement in reducing the incidence of xerostomia with bilateral superficial lobe parotid sparing IMRT.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| oropharyngeal and hypopharyngeal HNSCC | Intensity Modulated Radiotherapy HPV positive and HPV negative |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intensity modulated radiotherapy | Radiation | Bilateral superficial lobe parotid sparing intensity modulated radiotherapy |
|
| Measure | Description | Time Frame |
|---|---|---|
| The proportion of patients reporting grade 2 or more xerostomia using subjective measure on the LENTSOMA late toxicity scoring scale one year after treatment. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Acute radiation toxicity | 0-3 months | |
| Late radiation toxicity | 3-24 months | |
| Survival outcomes for entire cohort and according to HPV status where available : Local control, Loco regional control, Loco-regional progression-free survival (LRPFS), Disease free survival, Overall survival. |
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Inclusion Criteria:
Exclusion Criteria:
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Midline pharyngeal squamous cell cancers (excluding nasopharyngeal cancers)
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| Name | Affiliation | Role |
|---|---|---|
| Christopher M Nutting, FRCR | Royal Marsden NHS Foundation Trust | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Head and Neck Unit, Royal Marsden Hospital | London | SW3 6JJ | United Kingdom |
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| ID | Term |
|---|---|
| D050397 | Radiotherapy, Intensity-Modulated |
| ID | Term |
|---|---|
| D020266 | Radiotherapy, Conformal |
| D011881 | Radiotherapy, Computer-Assisted |
| D011878 | Radiotherapy |
| D013812 | Therapeutics |
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| 24 months |