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The purpose of this study is to explore the mechanisms behind how sleep quality may affect skin aging, skin integrity and skin disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal, healthy volunteers | Normal, healthy volunteers without any skin pathology will be asked to undergo various procedures to evaluate their sleep and skin health. | ||
| Volunteers with skin pathology | Volunteers with skin pathology including but not limited to eczema, psoriasis, acne, and other inflammatory dermatoses will be asked to undergo various procedures to evaluate their sleep and skin health. |
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| Measure | Description | Time Frame |
|---|---|---|
| Analysis of Sleep Pattern via Actigraphy, Polysomnography & Questionnaires | The volunteers may be asked to wear a wrist actigraph to measure movement. This watch would be worn for 24 hours per day for 7-14 days. The volunteer may also be asked to fill out questionnaires regarding their sleep patterns. Note: Other methods of assessing sleep patterns may also be used including a portable polysomnogram or a standard, overnight sleep study. | 7-14 days |
| Evaluation of skin (both in terms of skin aging and skin disease) | The volunteers may have their skin evaluated for skin aging using the SCINEXA tool. Volunteers with psoriasis may have their skin evaluated via PASI and/or PGA assessments. Volunteers may have photographs taken to compare clinical appearance with laboratory and research findings. | Only once during the study or at specific time points depending on what other procedures are being performed |
| Measure | Description | Time Frame |
|---|---|---|
| Sample Analysis (from skin, blood, urine, saliva and hair follicle samples) | Skin, blood, urine, saliva and hair follicle samples may be collected from some volunteers to look at various markers related to sleep, the circadian rhythm and skin disease. | Only once during the study or at specific time points depending on what other procedures are being performed |
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Inclusion Criteria:
Exclusion Criteria:
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Adults from Northeast Ohio who are either healthy, normal volunteers or have skin pathology including but not limited to eczema, psoriasis, acne, and other inflammatory dermatoses
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| Name | Affiliation | Role |
|---|---|---|
| Kevin Cooper, MD | University Hospitals Cleveland Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44118 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25266053 | Background | Oyetakin-White P, Suggs A, Koo B, Matsui MS, Yarosh D, Cooper KD, Baron ED. Does poor sleep quality affect skin ageing? Clin Exp Dermatol. 2015 Jan;40(1):17-22. doi: 10.1111/ced.12455. Epub 2014 Sep 30. | |
| 11316970 | Background | Rogiers V; EEMCO Group. EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences. Skin Pharmacol Appl Skin Physiol. 2001 Mar-Apr;14(2):117-28. doi: 10.1159/000056341. |
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| ID | Term |
|---|---|
| D011565 | Psoriasis |
| D004485 | Eczema |
| D000152 | Acne Vulgaris |
| ID | Term |
|---|---|
| D017444 | Skin Diseases, Papulosquamous |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D003872 | Dermatitis |
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Skin, blood, urine, saliva and hair follicle samples may be collected from volunteers to look at various markers related to sleep, the circadian rhythm and skin disease.
| Skin Barrier Recovery (via TEWL measurement) | Skin barrier recovery via Transepidermal Water Loss (TEWL) measurement may be assessed in some volunteers. | Only once during the study or at specific time points depending on what other procedures are being performed |
| MED Testing & Recovery from UV-induced erythema | MED Testing & Recovery from UV-induced erythema may be assessed in some volunteers. | 24 hours |
| 19059763 | Background | Vierkotter A, Ranft U, Kramer U, Sugiri D, Reimann V, Krutmann J. The SCINEXA: a novel, validated score to simultaneously assess and differentiate between intrinsic and extrinsic skin ageing. J Dermatol Sci. 2009 Mar;53(3):207-11. doi: 10.1016/j.jdermsci.2008.10.001. Epub 2008 Dec 6. |
| D017443 | Skin Diseases, Eczematous |
| D017486 | Acneiform Eruptions |
| D012625 | Sebaceous Gland Diseases |