Antibiotic Dosing in Pediatric Intensive Care

Antibiotic Dosing in Pediatric Intensive Care

Pharmacokinetics of antibiotics in critically ill neonates, infants and children

Inclusion Criteria:

• patients admitted to the pediatric intensive care unit
• patient age/weight : 1,8 kg-15 years
• patient receiving antibiotic treatment (piperacillin-tazobactam, amoxicillin-clavulanate, vancomycin, teicoplanin, meropenem, ciprofloxacin, amikacin) via intermittent infusion regimen or continuous infusion according to institutional treatment guidelines
• intra-arterial or intravenous access other than the drug infusion line available for blood sampling (arterial line is preferred)

Exclusion Criteria:

• no catheter in place for blood sampling
• absence of parental/patient consent
• known hypersensitivity to beta-lactam antibiotics, glycopeptides, fluoroquinolones, aminoglycosides
• extracorporeal circuit (haemodialysis, ECMO, peritoneal dialysis )