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| Name | Class |
|---|---|
| University Hospital, Antwerp | OTHER |
| Queen Fabiola Children's University Hospital (HUDERF/UKZKF) | UNKNOWN |
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Pharmacokinetics of antibiotics in critically ill neonates, infants and children
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| amoxicillin-clavulanate | Patients receiving amoxicillin-clavulanate as part of routine clinical care. |
| |
| piperacilline-tazobactam | Patients receiving piperacilline-tazobactam as part of routine clinical care. |
| |
| vancomycin | Patients receiving vancomycin as part of routine clinical care. |
| |
| teicoplanin | Patients receiving teicoplanin as part of routine clinical care. |
| |
| meropenem | Patients receiving meropenem as part of routine clinical care. |
| |
| ciprofloxacin |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood sampling in patients receiving amoxicillin-clavulanate as part of routine clinical care | Procedure |
| ||
| Measure | Description | Time Frame |
|---|---|---|
| To investigate if first-dose blood concentrations with maximum antimicrobial activity are achieved with current dosing regimens. | 2 years (expected) | |
| To investigate if steady-state blood concentrations with maximum antimicrobial activity are achieved with current dosing regimens. | 2 years (expected) |
| Measure | Description | Time Frame |
|---|---|---|
| To compare measured first-dose blood concentrations with predefined pharmacodynamic targets (Time above MIC) | 2 years (expected) | |
| To compare measured steady-state blood concentrations with predefined pharmacodynamic targets (Time above MIC) | 2 years (expected) |
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Inclusion Criteria:
Exclusion Criteria:
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children admitted to a neonatal or pediatric intensive care unit
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Pieter De Cock, PharmD | Contact | +32 9 332 29 69 | pieter.decock@uzgent.be |
| Name | Affiliation | Role |
|---|---|---|
| Pieter De Cock | University Hospital, Ghent | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ghent University Hospital, Hospital Pharmacy | Recruiting | Ghent | 9000 | Belgium |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40239747 | Derived | Dhont E, Standing JF, Beel E, Nguyen TVA, Herck I, Peperstraete H, Vandenberghe W, Bove T, Vandekerckhove K, Verougstraete N, Stove V, Vande Walle J, De Paepe P, De Cock PA. Individualised amoxicillin-clavulanate dosing recommendations for critically ill children with augmented clearance after cardiac surgery. Int J Antimicrob Agents. 2025 Aug;66(2):107513. doi: 10.1016/j.ijantimicag.2025.107513. Epub 2025 Apr 15. | |
| 35426861 |
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blood samples and urine samples (only for ciprofloxacin)
Patients receiving ciprofloxacin as part of routine clinical care. |
|
| amikacin | Patients receiving amikcain as part of routine clinical care. |
|
| blood sampling in patients receiving piperacilline-tazobactam as part of routine clinical care. |
| Procedure |
|
| blood sampling in patients receiving vancomycin as part of routine clinical care. | Procedure |
|
| blood sampling in patients receiving teicoplanin as part of routine clinical care. | Procedure |
|
| blood sampling in patients receiving meropenem as part of routine clinical care. | Procedure |
|
| blood sampling and urine smapling in patients receiving ciprofloxacin as part of routine clinical care. | Procedure |
|
| blood sampling in patients receiving amikacin as part of routine clinical care. | Procedure |
|
| Derived |
| Van Der Heggen T, Dhont E, Willems J, Herck I, Delanghe JR, Stove V, Verstraete AG, Vanhaesebrouck S, De Paepe P, De Cock PAJG. Suboptimal Beta-Lactam Therapy in Critically Ill Children: Risk Factors and Outcome. Pediatr Crit Care Med. 2022 Jul 1;23(7):e309-e318. doi: 10.1097/PCC.0000000000002951. Epub 2022 Apr 15. |
| 33030704 | Derived | Aulin LBS, De Paepe P, Dhont E, de Jaeger A, Vande Walle J, Vandenberghe W, McWhinney BC, Ungerer JPJ, van Hasselt JGC, De Cock PAJG. Population Pharmacokinetics of Unbound and Total Teicoplanin in Critically Ill Pediatric Patients. Clin Pharmacokinet. 2021 Mar;60(3):353-363. doi: 10.1007/s40262-020-00945-4. Epub 2020 Oct 8. |
| 27999035 | Derived | De Cock PA, Desmet S, De Jaeger A, Biarent D, Dhont E, Herck I, Vens D, Colman S, Stove V, Commeyne S, Vande Walle J, De Paepe P. Impact of vancomycin protein binding on target attainment in critically ill children: back to the drawing board? J Antimicrob Chemother. 2017 Mar 1;72(3):801-804. doi: 10.1093/jac/dkw495. |
| 26349821 | Derived | De Cock PA, Standing JF, Barker CI, de Jaeger A, Dhont E, Carlier M, Verstraete AG, Delanghe JR, Robays H, De Paepe P. Augmented renal clearance implies a need for increased amoxicillin-clavulanic acid dosing in critically ill children. Antimicrob Agents Chemother. 2015 Nov;59(11):7027-35. doi: 10.1128/AAC.01368-15. Epub 2015 Sep 8. |
| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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