Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO)

Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation

Pharmacokinetics of antibiotics in critically ill neonates, infants and children on extracorporeal membrane oxygenation (ECMO).

The study will investigate whether - with the current dosing regimens of meropenem, piperacillin-tazobactam, amoxicillin-clavulanate, cephazolin, vancomycin, amikacin, teicoplanin and ciprofloxacin - pharmacodynamic targets are attained in a national multicentric clinical setting in pediatric patients on ECMO.

Inclusion Criteria:

• patients admitted to the pediatric intensive care unit or cardiac intensive care unit
• patient age : 1,8 kg-15 years
• patient receiving antibiotic treatment (piperacillin-tazobactam, meropenem, amoxicillin-clavulanate, cephazolin, vancomycin, teicoplanin, ciprofloxacin, amikacin)
• intra-arterial or intravenous access other than the drug infusion line available for blood sampling (arterial line is preferred)
• extracorporeal membrane oxygenation circuit

Exclusion Criteria:

• no catheter in place for blood sampling
• absence of parental/patient consent
• known hypersensitivity to beta-lactam antibiotics and ciprofloxacin