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| Name | Class |
|---|---|
| U.S. National Science Foundation | FED |
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The main objective of this project is to study whether intranasal oxytocin (OT) affects how young adults perceive and attend to infant and adult faces. Based on existing research the investigators predict that oxytocin will facilitate the allocation of attentional resources on infant faces (compared to adult faces). The investigators also predict that oxytocin will enhance the activity of reward neural-networks associated with the perception of infant faces. The behavioral effects of OT (visual attention and face recognition) will be measured with eye-tracking while participants look at photographs of adult and infant faces. Neurological effects (the activity of emotion and reward networks) will be measured with functional Magnetic Resonance Imaging (fMRI) while participants look at infant faces on a computer screen.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intranasal oxytocin group | Experimental | Participants will self-administer a single dose of 24 IU oxytocin (Syntocinon, Novartis; three puffs per nostril, each with 4 IU oxytocin, 6 puffs total). |
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| Placebo group | Placebo Comparator | The placebo is identical to the oxytocin formulation with the exception of the active compound. Participants will self-administer three puffs per nostril of placebo (6 puffs total). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Syntocinon (synthetic oxytocin) | Drug | Dosage and details described in arm. |
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| Measure | Description | Time Frame |
|---|---|---|
| Functional Magnetic Resonance Imaging (fMRI) Data | The effect of OT will be assessed by determining changes in brain activation between treatment and placebo groups. | 45 minutes after OT manipulation |
| Eye movements data | The effect of OT will be assessed by determining changes in eye movements between treatment and placebo groups. | 45 minutes after OT manipulation |
| Measure | Description | Time Frame |
|---|---|---|
| Implicit Attitudes toward infants | Implicit attitudes toward infants as measured by the Implicit Association Test | 45 minutes after OT manipulation |
| Theory of mind | Theory of mind as measured by the Reading the mind in the eyes test |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rodrigo A Cardenas, PhD | Penn State University | Principal Investigator |
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| ID | Term |
|---|---|
| D010121 | Oxytocin |
| ID | Term |
|---|---|
| D010909 | Pituitary Hormones, Posterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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| Placebo | Other | Dosage and details described in arm. |
|
| 45 minutes after OT manipulation |
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |