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| ID | Type | Description | Link |
|---|---|---|---|
| 2014-000571-50 | EudraCT Number |
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Ultrasound guidance can reduce the required local anesthetic volume for successful peripheral nerve block.
The aim of the study is to determine the minimum volume of local anesthetic to achieve an ultrasound-guided median nerve block with a dextrose 5% hydrodissection approach.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| median nerve block | Experimental | An ultrasound-guided nerve block with dextrose 5% hydrodissection is performed in each case. The first patient will receive a 2 mL local anesthetic solution. For following patients, the volume of local anesthetic depends on the clinical result of the previous patient:
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| median nerve block | Procedure |
|
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| Measure | Description | Time Frame |
|---|---|---|
| Minimal effective volume of local anesthetic | Effective volume of local anesthetic to obtain a successful median nerve block block in 95% of patients defined as complete light touch block at the palmar aspect of the 2 distal phalanges of the index finger during a 30 minute evaluation period (mL) | 1 hour |
| Measure | Description | Time Frame |
|---|---|---|
| Nerve block onset time | Onset time for complete cold light touch and motor block at 30 min and 45 min. | 1 hour |
| Success rate of the median nerve block | Success rate concerns:
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Inclusion Criteria:
Exclusion Criteria:
Exclusion from the study:
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| Name | Affiliation | Role |
|---|---|---|
| Eric Dufour, MD | Centre Hospitalier de la Côte Basque, 64100 Bayonne, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier de la Côte Basque | Bayonne | 64100 | France | |||
| Hopital privé de l'Ouest Parisien |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34996918 | Derived | Dufour E, Jaziri S, Novillo MA, Aubert L, Chambon A, Kutz R, Vallee A, Fischler M. A randomized trial to determine the minimum effective lidocaine volume for median nerve block using hydrodissection. Sci Rep. 2022 Jan 7;12(1):52. doi: 10.1038/s41598-021-03660-7. |
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| ID | Term |
|---|---|
| D008012 | Lidocaine |
| D004837 | Epinephrine |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 |
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Ascending dose model
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| 1 hour |
| Additional local anesthetic |
| 2 hours |
| Duration of analgesia | Time to first analgesic requirement (minutes) | 1 day |
| Duration of the block | Delay between the completion of the block and the returned to normal onset of sensory and motor recovery of the first three fingers of the hand) (minutes) | 1 day |
| Complications |
| 1 month |
| Block procedure time | Time taken to perform hydrodissection with dextrose 5% and inject the local anesthetic (min) | One hour |
| Trappes |
| 78190 |
| France |
| Aniline Compounds |
| D000588 | Amines |
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D015306 | Biogenic Monoamines |
| D001679 | Biogenic Amines |
| D002395 | Catecholamines |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |