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In this study, up to 20 healthy individuals, 20 endo-ACAB patients, and 20 CABG patients undergo a maximal cardiopulmonary exercise test after hospital discharge (for patients only). Exercise tolerance is compared between groups.
In this prospective observational study, up to 20 healthy individuals (no history or presence of any chronic disease, sedentary), 20 endo-ACAB patients, and 20 CABG patients (matched for age, gender and BMI) undergo a maximal cardiopulmonary exercise test after hospital discharge (for patients only).During this exercise test, following parameters are assessed at peak effort and at the second ventilatory threshold (determined by VE/VCO2 slope method): oxygen uptake (VO2), oxygen saturation (SaO2), carbon dioxide output (VCO2), resoiratory gas exchange ratio (RER), expiratory volume (VE), ventilatory equivalent for VCO2 (VE/VCO2), ventilatory equivalent for VO2 (VE/VO2), end-tidal O2 pressure (PETO2), end-tidal CO2 pressure (PETCO2), heart rate (HR), oxygen pulse (VO2/HR), cycling power output (W), tidal volume (Vt), respiratory rate (RR), systolic blood pressure (SBP), diastolic blood pressure (DBP), rate pressure product (RPP). Peak exercise effort is validated by RERpeak.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy individuals | Age, gender and BMI matched healthy subjects without any chronic disease or physical disability, and being sedentary. |
| |
| CABG patients | Age, gender and BMI matched CABG patients, without neurologic, nephrologic, respiratory disease. |
| |
| endo-ACAB patients | Age, gender and BMI matched endo-ACAB patients without neurologic, nephrologic, respiratory disease. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cardiopulmonary exercise test | Other | Maximal exercise test with ergospirometry. |
|
| Measure | Description | Time Frame |
|---|---|---|
| VO2peak (peak oxygen uptake) | Peak oxygen uptake capacity, expressed as ml/min. | At peak exercise, single measurement which is executed between 2-4 weeks after surgery. |
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Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing CABG surgery or endo-ACAB surgery.
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| Name | Affiliation | Role |
|---|---|---|
| Paul Dendale | Jessa Hospital, Stadsomvaart 11, 3500 Hasselt, Belgium | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jessa Hospital | Hasselt | 3500 | Belgium |
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| ID | Term |
|---|---|
| D005080 | Exercise Test |
| ID | Term |
|---|---|
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| D012129 | Respiratory Function Tests |
| D003948 | Diagnostic Techniques, Respiratory System |
| D016552 | Ergometry |
| D008919 | Investigative Techniques |