The rationale for the proposed pilot study is to investigate the ability of PET-CT with F18-choline to detect and locate the parathyroid adenoma in patients with primary hyperparathyroidism and negative or non-contributory MIBI (Tc-99m sestamibi) and cervical ultrasound, in order to avoid unnecessary bilateral cervical exploration.

Inclusion Criteria:

• Patient aged 18 years or more;
• Patient with a primary hyperparathyroidism and witj a negative or non-contriburatory MIBI parathyroid scintigraphy and neck ultrasonography, for which surgical resection is planned;
• Confirmation of the diagnosis of primary hyperparathyroidism on laboratory tests
• Affiliate to a social security system;
• Patient written informed consent.

Exclusion Criteria:

• Patient deprived of liberty, under guardianship;
• Any medical or psychological condition witch could compromise the capacity of the patient to participate in the study;
• Pregnant or breastfeeding