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| Name | Class |
|---|---|
| Spaulding Rehabilitation Hospital | OTHER |
| Beth Israel Deaconess Medical Center | OTHER |
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The purpose of this feasibility study is to preliminarily evaluate the effects of Tai Chi - a mind-body exercise - on motor and cognitive function as well as quality of life in individuals recently diagnosed with Parkinson's disease (PD).
Specific Aim 1: To assess the feasibility of recruiting and retaining individuals with PD into a 6-month randomized controlled trial of Tai Chi exercise.
Specific Aim 2: To collect preliminary data on the efficacy of Tai Chi on improving gait and balance dynamics, physical and cognitive function, exercise activity, self-efficacy, mood, and quality of life in individuals with PD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tai Chi | Experimental | 6-month Tai Chi training program combined with usual medical care |
|
| Usual Care | No Intervention | Waitlist control group receiving usual medical care alone |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tai Chi | Other | 6-month Tai Chi exercise program meeting 2 times per week plus DVD for home practice |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of participant recruitment | 24 months | |
| Protocol adherence | The percentage of Tai Chi classes attended and home practice completed by each participant randomized to the experimental arm. | 6 months |
| Retention | The percentage of study visits completed by each participant. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change from Baseline in Unified Parkinson's Disease Rating Scale (UPDRS) | Motor symptom severity | Baseline and 6 months |
| Change from Baseline in PDQ-39 | PD-related quality of life |
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Inclusion Criteria:
Exclusion Criteria:
Diagnosis of any form of atypical parkinsonism
History of: stroke, head trauma, brain tumor, brain injury, seizures or other central nervous system condition, orthopedic impairment or other disease that could likely contribute to a gait disturbance or parkinsonism
Any severe, chronic condition or acute medical event for which participation in exercise programs is contraindicated (e.g. debilitating Rheumatoid Arthritis, history of frequent falls, unhealed fracture)**
** Unless the participant is able to obtain formal written approval from his/her treating physician granting permission to participate in our Tai Chi exercise program
Participation in brain stimulation within the past 3 months
Family history of seizures or unexplained loss of consciousness
Current history of dementia or severe psychiatric illness. Patients with mild (non-suicidal) depression and/or anxiety may be included
Acute illness requiring hospitalization within past 3 months
History of deep brain stimulation or other brain surgery
Participation in brain stimulation within the past 3 months
Regular use of walking aid
Significant Tai Chi experience (> 6 months training in past 2 years)
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| Name | Affiliation | Role |
|---|---|---|
| Peter M Wayne, PhD | Harvard University Faculty of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brigham and Women's Hospital | Boston | Massachusetts | 02215 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38588457 | Derived | Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2024 Apr 8;4(4):CD013856. doi: 10.1002/14651858.CD013856.pub3. | |
| 36602886 |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D026302 | Tai Ji |
| ID | Term |
|---|---|
| D026441 | Mind-Body Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026241 | Exercise Movement Techniques |
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| Baseline and 6 months |
| Change from Baseline in Physical Activity Status Scale (PASS) | Baseline and 6 months |
| Change from Baseline in Self-Efficacy for Exercise Scale | Baseline and 6 months |
| Change from Baseline in Activity-specific Balance Confidence Scale | Baseline and 6 months |
| Change from Baseline in Profile of Mood State | Baseline and 6 months |
| Change from Baseline in Single leg stance time | Baseline and 6 months |
| Change from Baseline in Timed Up and Go Test | Baseline and 6 months |
| Change from Baseline in Steady state gait dynamics | Steady state gait dynamics during 90 seconds of continuous over ground walking at preferred speed with and without use of dual task challenges | Baseline and 6 months |
| Change from Baseline in Balance/Postural control | Sway based measures of balance during quiet and tandem standing, with and without dual tasks | Baseline and 6 months |
| Change from Baseline in Cognitive function | Trail Making Test (TMT), The Digit Span Test, Controlled Oral Word Association Test (COWAT), Stroop Color-Word Test | Baseline and 6 months |
| Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023 Jan 5;1(1):CD013856. doi: 10.1002/14651858.CD013856.pub2. |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D026741 |
| Physical Therapy Modalities |