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The purpose of this study is to investigate the potential healing properties of phenytoin.
The investigators will use the donor site of a split skin thickness graft (SSTG) to model a basic wound in a randomized controlled trial of topical phenytoin against current best clinical practice. The investigators aim to demonstrate a dose dependent effect. The investigators hypothesis, based on previous clinical experience at our center and on current available literature, that phenytoin will reduce wound healing time.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Active Comparator | Dressings of best current clinical practice, sugar solution. |
|
| Phenytoin 1 | Experimental | Dressings using phenytoin solution 20mg/ml |
|
| Phenytoin 2 | Experimental | Dressings using phenytoin solution 40mg/ml |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phenytoin | Drug | Topical use of phenytoin solution on dressings of split thickness skin graft sites. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage rate of re-epithelialization | Pictures taken of wound site every other day will be analysed using imaging software for size of wound. Percentage rate will be calculated from this. | Participants will be followed for the duration of hospital stay, an expected average of 20 days |
| Appearance of infection | Pictures taken of wound site every other day will be analysed using imaging software and the Southampton wound grading scale | Participants will be followed for the duration of hospital stay, an expected average of 20 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jim Gollogly | Contact | +85512979214 | jim@csc.org |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Children's Surgical Centre | Recruiting | Phnom Penh | Cambodia |
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| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D010672 | Phenytoin |
| ID | Term |
|---|---|
| D006827 | Hydantoins |
| D048289 | Imidazolidines |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 |
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| Sugar solution | Drug |
|
| Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |