Assessing the Effects of Tretinoin Cream on Human Skin With Optical Imaging Technologies

In-vivo Non-invasive Skin Imaging Pilot Study to Assess the Effects of Tretinoin Cream Using Multi-photon Microscopy and Multi-spectral Imaging

The researchers will assess the effects of treatment with tretinoin cream on human skin by using non-invasive optical imaging technologies.

The researchers will evaluate changes in the dermis and skin properties as the effect of treatment with Tretinoin cream (0.1%) by using the following optical imaging techniques.

1. Multiphoton microscopy using a clinical tomograph (MPTflex, Jenlab, Germany)
2. Multispectral Imaging using a device developed at Beckman Laser Institute, UC Irvine

Inclusion Criteria:

• Female 45 years of age or older - Skin type scale I to III

Exclusion Criteria:

• Large amount of dark, coarse hair on the arms
• History of allergies to alpha hydroxy acids (AHAs), retinoids, soaps, fragrances, sunscreens or Latex
• Currently using over-the-counter AHA or retinol within one month or prescription retinoid within three months of the start of the study.
• History of skin cancer, including squamous or basal cell carcinoma at the treatment site or history of malignant melanoma.
• History of diabetes
• Currently pregnant or nursing