Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles

Double-blinded, Single-center, Parallel-arm Comparison Study of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage

The purpose of this study is to assess the comparative efficacy of retinol 1.0% and tretinoin 0.02% in minimizing wrinkles, discoloration, roughness, and other signs of moderate to severe photodamage. Our hypothesis is that both products will be of comparable benefit.

Inclusion Criteria:

• Age 35 or over
• Moderate to severe photodamage

Exclusion Criteria:

• History of facial cosmetic surgery, facial resurfacing procedures, deep peels, or facial fillers
• History of keloids or hypertrophic scars
• Use of oral steroids or oral retinoids (such as Accutane) in past 6 months