To study the effects of Flaxseed supplement on weight, lipid profile and inflammatory factors in subjects with over weight and obesity, 50 patients will be randomly allocated to receive placebo or 30 grams milled Flaxseed for 12 weeks; both groups will be advised to adherence the investigators' diet and exercise program too. At the first and the end of the intervention, weight, waist and hip circumference, lipid profile and some inflammatory markers will be assessed and compared between groups.

Inclusion Criteria:

• Age of 18 to 70 years
• Body Mass Index (BMI) between 25-40

Exclusion Criteria:

• diabetes mellitus
• cardiovascular diseases and cancers
• major systemic diseases
• gastrointestinal problems
• liver and renal failure
• history of allergy or high consumption of nuts, flaxseed, or sesame seeds
• weight loss within the past 6 mo of >5% of body weight or current adherence to a weight-reduction diet
• pregnancy, lactation