Effect of a High-fat Meal on the Pharmacokinetics of Hetrombopag and Mass Balance Study in Healthy Subjects

Effect of a High-fat Meal on the Pharmacokinetics of Hetrombopag and Mass Balance Study in Healthy Subjects

This open-label, randomized, two-period, two-treatment (single doses of 7.5 mg hetrombopag fasted or fed), crossover study was conducted to evaluate the effect of a high-fat meal on the pharmacokinetics of hetrombopag and mass balance study in 12 healthy subjects.

Inclusion Criteria:

• Healthy.
• Weight≥50 kg，19≤BMI≤28 kg/m2.
• Platelet count is within normal range

Exclusion Criteria:

• History of clinically significant illness.
• History of alcohol or drug abuse.