Rhinosinusites Chroniques

ETUDE DU MICROBIOTE DES RHINOSINUSITES CHRONIQUES DIFFICILES A TRAITER PAR METAGENOMIQUE ET CULTUROMIQUE

To analyse and describe sinus microbiota, during hard to treat (or refractory) rhinosinusitis, using culturomic and metagenomic methods (i.e. to culture on many different medium of culture to grow hard to cultivate bacteria + to sequence and analyse all DNA contained in samples).

Samples are middle meatus swabs or pus aspiration, done during usually patient following.

Inclusion Criteria:

• >18 year old
• chronic refractory rhinosinusitis
• to require middle meatus swab or other sinus sample
• absence of opposition

Exclusion Criteria:

• <18 year old
• pregnant women
• breastfeeding
• under trusteeship
• under guardianship