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Twenty four patients with bone resorption on the anterior maxilla will be divided into two groups with different kinds of grafting: bone block associated with particulated biomaterial and particulated mixture of autogenous bone and biomaterial stabilized by collagen membrane and pins. The techniques will be compared according to volume gain, quality of graft osseointegration, implant survival and maintenance of the level of soft tissues.
Twenty four patients will be selected analysing the resorption on the front maxilla and will be divided into two groups. Experimental group will receive a particulated mixture of autogenous and lyophilized bovine bone, stabilized with a collagen membrane and pins over the vertical and/or horizontal defect, while Control group will receive a bone block graft, stabilized with fixation screws , covered with lyophilized bone and a collagen membrane. After a period of nine months, the volume increase will be measured trough the difference found between the initial computerized tomography and the final computerized tomography.
Dental implants will be placed according to the prosthetic need and bone cylinders will be removed from the respective location. The cylinders will be histologically analysed in order to verify the quality of the graft osteointegration. After the prosthesis installation, the implant survival and the soft and hard tissues will be followed up for a minimum period of 24 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sausage graft | Experimental | Bone graft performed with a mixture of particulated autogenous and lyophilized bovine bone, stabilized with collagen membrane and pins. |
|
| Bone block graft | Active Comparator | Bone graft performed with a block of autogenous bone stabilized by a screw associated with lyophilized bovine bone and collagen membrane. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biopsy | Procedure | A cylinder of grafted bone will be removed from the location elected for the implant installation with an appropriate trephine |
|
| Measure | Description | Time Frame |
|---|---|---|
| vertical gain | Measures will be taken from computerized tomography in axial sections | 9 months |
| horizontal gain | Measures will be taken from computerized tomography in transverse sections | 9 months |
| implants survival | Clinical examination and standardized radiographs will be taken periodically | 24 months |
| soft tissue volume | Measures will be taken from images generated by intraoral scanning in an occlusal view | 24 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Caroline B Keedi, MSD | Contact | 55 11 997981436 | carolbkeedi@gmail.com | |
| Patricia S Gimenez, MSD | Contact | 55 11 983832404 | patsgimenez@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Pedro Tortamano, PHD | University of Sao Paulo | Principal Investigator |
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| Computerized Tomography | Radiation | An initial computerized tomography will be made before the first surgery, and a final computerized tomography will be made after 9 months, previously to the second surgery |
|
| Standardized periapical radiographs | Other | A device will be adopted for the standardization, and radiographs will be taken at day 0, 3 months, 6 months, 12 months, 18 months, 24 months after implant installation |
|
| Intraoral scanning | Other | Intraoral scanning will be made before the graft, at implant installation, 3 months, 6 months, 12 months, 18 months, 24 months after implant installation |
|
| ID | Term |
|---|---|
| D019048 | Prostatic Intraepithelial Neoplasia |
| ID | Term |
|---|---|
| D002278 | Carcinoma in Situ |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D001706 | Biopsy |
| ID | Term |
|---|---|
| D003581 | Cytodiagnosis |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D013048 | Specimen Handling |
| D003949 | Diagnostic Techniques, Surgical |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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