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| ID | Type | Description | Link |
|---|---|---|---|
| 2013-A00337-38 | Registry Identifier | ID RCB |
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The investigators want to compare blood microbiota profile between patients with documented coronary lesions and patients free of coronary disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| case | patients with a myocardial infarction within one month to one year before the inclusion | ||
| control | patients without history of myocardial infarction, free of coronary disease in the view of one of the following test performed within one year before the inclusion : Effort test Echocardiographic stress test Myocardial perfusion scintigraphy Coronarography with >= 2 major cardiovascular risk factors :
|
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| Measure | Description | Time Frame |
|---|---|---|
| blood bacterial 16s rDNA bacterial gene concentration | compare blood bacterial 16s rDNA bacterial gene concentration | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| blood microbiota profile | compare blood microbiota profile as assessed at all taxonomic levels of interest (genus, family, order, class, phylum) | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| lipid profile | Obtain an accurate lipid profile with a new technic of microelectrophoresis(Lipoprint) | 12 months |
| functional HDL | Analyse the functional qualities of the HDL from the serum |
Inclusion Criteria:
Effort test Echocardiographic stress test Myocardial perfusion scintigraphy Coronarography with >= 2 major cardiovascular risk factors:
Exclusion Criteria:
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case : patients who have had a myocardial infarction within one month to one year before the inclusion controls : patients without history of myocardial infarction, free of coronary disease in the view of one of the following tests performed within one year before the inclusion Effort test Echocardiographic stress test Myocardial perfusion scintigraphy Coronarography with >= 2 major cardiovascular risk factors:
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| Name | Affiliation | Role |
|---|---|---|
| Meyer Elbaz, PhD | University Hospital, Toulouse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UHToulouse | Toulouse | 31000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38432214 | Derived | Grazide MH, Ruidavets JB, Martinet W, Elbaz M, Vindis C. Association of Circulating Autophagy Proteins ATG5 and Beclin 1 with Acute Myocardial Infarction in a Case-Control Study. Cardiology. 2024;149(3):217-224. doi: 10.1159/000537816. Epub 2024 Mar 2. | |
| 31566105 | Derived | Amar J, Lelouvier B, Servant F, Lluch J, Burcelin R, Bongard V, Elbaz M. Blood Microbiota Modification After Myocardial Infarction Depends Upon Low-Density Lipoprotein Cholesterol Levels. J Am Heart Assoc. 2019 Oct;8(19):e011797. doi: 10.1161/JAHA.118.011797. Epub 2019 Sep 28. |
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| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D009203 | Myocardial Infarction |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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blood sample
| 12 months |
| microARN profile | Search a microARN profile corresponding to the coronary heart disease | 12 months |
| Serum Bank and DNA Bank | Form a Serum Bank and a DNA Bank for potential future analysis guided by microARN research | 10 years |
| modifications of the blood microbiota | Analyse modification of the blood microbiota in the case and the control | 12 months |
| D007238 |
| Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |