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The investigators will compare 16sRDNA profile in cases and controls in order to identify bacteria associated with metabolic diseases that reside both in intestinal crypts and in blood.
Experimental evidence suggests that bacterial translocation from gut to tissue could be an initial step leading to diabetes. To test this hypothesis, a bacterial component that is highly conserved between different species of bacteria, the 16S rDNA gene will be analysed both in intestinal crypt and in blood in patients with type 2 diabetes, obese patients and control.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| obese patients | Experimental | Total blood sample, and 4 biopsies : collection of 2 colonic and 2 ileal biopsies |
|
| Diabetic patients | Experimental | Total blood sample, and 4 biopsies : collection of 2 colonic and 2 ileal biopsies |
|
| Patients free of obesity and diabetes | Experimental | Total blood sample, and 4 biopsies : collection of 2 colonic and 2 ileal biopsies |
|
| patients free type 2 diabetes. | Experimental | Total blood sample, and 4 biopsies : collection of 2 colonic and 2 ileal biopsies |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| obese patients | Other | collection of blood sampling and biopsies |
| |
| Measure | Description | Time Frame |
|---|---|---|
| rDNA comparison between cases and controls | Comparison of 16sRDNA profile in cases and controls in order to identify bacteria associated with metabolic diseases that reside both in intestinal crypts and in blood. | 36 months |
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Inclusion Criteria:
Diabetes population:
Obese population:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jacques AMAR, MD PhD | University Hospital, Toulouse | Study Director |
| Jacques Moreau, MD | University Hospital, Toulouse | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Toulouse | Toulouse | 31 052 | France |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| diabetic patients |
| Other |
collection of blood sampling and biopsies |
|
| patients free of obesity and diabetes | Other | collection of blood sampling and biopsies |
|
| patients free type 2 diabetes | Other | collection of blood sampling and biopsies |
|
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D004700 | Endocrine System Diseases |