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| ID | Type | Description | Link |
|---|---|---|---|
| R01AG048811 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
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Growing up in a low-income household has been shown to increase risk for, and susceptibility to many illnesses.The purpose of the study is to test an affective intervention for reversing biological risk factors, as related to childhood adversity, in midlife.
Participants will be asked to make two lab visits; attend six weekly, 1-hour meditation classes; as well as complete brief online daily surveys for 11 weeks, five biweekly surveys, and two 30-minute surveys prior to each lab visit. During the lab visits, participants will have their psychophysiology monitored for heart rate, blood pressure, respiration, and pulse. Participants will also have their blood drawn.
All surveys and questionnaires inquire about participants' current demographics, family history, perceptions about life and well-being, physical health, and monetary choices.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lovingkindness | Experimental | A six-week formal meditation workshop for 1 hour per week. |
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| Mindfulness | Placebo Comparator | A six-week formal meditation workshop for 1 hour per week. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Meditation Workshop | Behavioral | Six weeks of formal instruction in Lovingkindness or Mindfulness meditation. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in meditation time (Self-reported meditation time recorded daily) | Self-reported meditation time recorded daily. | Weeks 3, 4, 5, 6, 7, 8, 9 ,10, 11, 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Leukocyte basal gene expression (evaluated through blood samples) | Gene expression evaluated through blood samples. | Week 0, Week 12 |
| Levels of mistrust (Self-report questionnaire measure of hostility using 9-item Cooke-Medley scale) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Barbara L Fredrickson, PhD | University of North Carolina, Chapel Hill | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UNC PEP Lab | Chapel Hill | North Carolina | 27514 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19617551 | Background | Miller GE, Chen E, Fok AK, Walker H, Lim A, Nicholls EF, Cole S, Kobor MS. Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14716-21. doi: 10.1073/pnas.0902971106. Epub 2009 Jul 14. | |
| 15272102 | Background | Cohen S, Doyle WJ, Turner RB, Alper CM, Skoner DP. Childhood socioeconomic status and host resistance to infectious illness in adulthood. Psychosom Med. 2004 Jul-Aug;66(4):553-8. doi: 10.1097/01.psy.0000126200.05189.d3. |
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Self-report questionnaire measure of hostility using 9-item Cooke-Medley scale.
| Week 0, Week 12 |
| Temporal Discounting (Monetary choice questionnaire to assess impulsive decision-making) | Monetary choice questionnaire to assess impulsive decision-making. | Week 0, Week 12 |
| Cardiac vagal tone (Respiration and echocardiogram measured with respiration band and 2-lead electrode placement) | Respiration and echocardiogram measured with respiration band and 2-lead electrode placement, respectively. Three-minute spontaneous breath followed by five minutes of paced breathing intervals. | Week 0, Week 12 |
| 21787044 | Background | Miller GE, Chen E, Parker KJ. Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol Bull. 2011 Nov;137(6):959-97. doi: 10.1037/a0024768. |
| 21300872 | Background | Cole SW, Hawkley LC, Arevalo JM, Cacioppo JT. Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3080-5. doi: 10.1073/pnas.1014218108. Epub 2011 Feb 7. |
| 20851735 | Background | Kok BE, Fredrickson BL. Upward spirals of the heart: autonomic flexibility, as indexed by vagal tone, reciprocally and prospectively predicts positive emotions and social connectedness. Biol Psychol. 2010 Dec;85(3):432-6. doi: 10.1016/j.biopsycho.2010.09.005. Epub 2010 Sep 22. |
| 36278141 | Derived | West TN, Zhou J, Brantley MM, Kim SL, Brantley J, Salzberg S, Cole SW, Fredrickson BL. Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households. Mindfulness (N Y). 2022 May;13(5):1185-1196. doi: 10.1007/s12671-022-01857-z. Epub 2022 Mar 16. |