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| Name | Class |
|---|---|
| Dairy Management Inc. | INDUSTRY |
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The specific aim of the proposed study is to address the efficacy of conventional full-fat dairy products as part of the normal routine diet for improving vascular function and reducing blood pressure in middle-aged and older adults with elevated blood pressure. The investigators hypothesize that dietary intervention including whole milk and full-fat milk products will induce significant decreases in systolic blood pressure and arterial stiffness. The investigators also test the hypothesis that the reductions in blood pressure will be associated with the corresponding decreases in arterial stiffness and/or increases in endothelial vasodilatory function as well as improvements in arterial baroreflex sensitivity. If our hypotheses are supported by the results, the information could be used as a basis for recommendations for the use of whole milk and full-fat milk products in the secondary prevention of elevated blood pressure and vascular dysfunction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dairy | Experimental | Add 4 daily servings of high fat dairy to diet for a period of 4 weeks |
|
| Plant-based | Active Comparator | Add 4 daily servings of fruit to diet and/or plant-based milk, remove all dairy from diet for a period of 4 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High fat dairy | Dietary Supplement | Add 4 daily servings per day of high fat dairy (yogurt, milk, cheese) for a period of 4 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Seated blood pressure | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| 24-hour ambulatory blood pressure | 4 weeks | |
| Carotid arterial compliance as measured by arterial pressure and corresponding cross-sectional area by ultrasound | 4 weeks | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tanaka Hirofumi, PhD | The University of Texas at Austin | Principal Investigator |
| Stephen J Roy, MS | The University of Texas at Austin | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Texas at Austin | Austin | Texas | 78712 | United States |
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| D058246 | Prehypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Plant-based | Dietary Supplement | Add 4 daily servings of fruit (fruit cup, apple sauce) and/or plant-based milk, remove all dairy for a period for 4 weeks |
|
| Arterial stiffness as measured by pulse wave velocity between the aortic arch and femoral artery |
| 4 weeks |
| Flow mediated dilation | 4 weeks |