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Elevated systolic blood pressure is by far the largest single contributor to cardiovascular risks in middle-aged and older adults. Lifestyle modifications, including dietary modifications, are the first line approach for treating and preventing hypertension. The general aim of the proposed study is to address the efficacy of conventional dairy products as part of the normal routine diet for lowing arterial blood pressure in middle-aged and older adults with elevated blood pressure. The investigators hypothesize that the dietary intervention including dairy products will induce significant decreases in arterial blood pressure in this population. A secondary aim will be to test the hypothesis that these reductions in systolic blood pressure will be associated with increases in arterial stiffness/compliance and endothelial vasodilatory function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dairy | Experimental | Add 4 daily servings of non-fat dairy to diet for a period of 4 weeks |
|
| Fruit | Active Comparator | Add 4 daily servings of fruit to diet, remove all dairy from diet for a period of 4 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-fat dairy | Dietary Supplement | Add 4 daily servings per day of non-fat dairy (yogurt, milk, cheese) for a period of 4 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Seated blood pressure | 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| 24-hour ambulatory blood pressure | 4 weeks | |
| Carotid arterial compliance | 4 weeks | |
| Arterial stiffness |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hirofumi Tanaka, PhD | University of Texas at Austin | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Texas at Austin, Cardiovascular Aging Research Laboratory | Austin | Texas | 78712 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25770758 | Derived | Machin DR, Park W, Alkatan M, Mouton M, Tanaka H. Effects of non-fat dairy products added to the routine diet on vascular function: a randomized controlled crossover trial. Nutr Metab Cardiovasc Dis. 2015 Apr;25(4):364-9. doi: 10.1016/j.numecd.2015.01.005. Epub 2015 Jan 31. | |
| 24808486 | Derived | Machin DR, Park W, Alkatan M, Mouton M, Tanaka H. Hypotensive effects of solitary addition of conventional nonfat dairy products to the routine diet: a randomized controlled trial. Am J Clin Nutr. 2014 Jul;100(1):80-7. doi: 10.3945/ajcn.114.085761. Epub 2014 May 7. |
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| ID | Term |
|---|---|
| D058246 | Prehypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| Add 4 servings fruit | Dietary Supplement | Add 4 daily servings of fruit (fruit cup, apple sauce, orange juice) and remove all dairy for a period for 4 weeks |
|
| 4 weeks |
| Flow mediated dilation | 4 weeks |