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| Name | Class |
|---|---|
| Nile Ivf Center, Cairo, Egypt | OTHER |
| Adam International Hospital | OTHER |
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To salvage the luteal phase and improve pregnancy rate in antagonist IVF/ICSI cycles triggered with GnRH agonist. Two strategies are compared supplementing the luteal phase with three small doses (500 IU) of HCG and giving a booster dose of HCG (1500 IU) on the day of ovum pickup.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Small doses of HCG | Active Comparator | Supplementing the luteal phase with three small doses (500 IU) of HCG after trigger with GnRH agonist in antagonist IVF/ICSI cycles in high responders |
|
| Booster HCG dose | Active Comparator | Booster HCG dose GnRH agonist only to trigger final maturation followed by a booster dose of 1500 IU of HCG on the day of ovum pickup |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IVF/ICSI | Procedure |
| ||
| Human Chorionic Gonadotropin |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate | The number of cycles with a positive pregnancy test and evidence of a gestational sac with fetal pulsations after 5weeks from pregnancy test | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| OHSS rate | The number of cycles with evidence of OHSS | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Chemical pregnancy rate | The number of cycles with a positive pregnancy test after 14 days from embryo transfer | 1 year |
| Early miscarriage rate | Pregnancies that end up with miscarriage before 12 weeks gestation |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sarwat Ahwany, MD | Cairo University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IVF centre, Obstetrics and Gynaecology Department, Cairo University Hospitals (Kasr EL Aini) | Cairo | Egypt | ||||
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D006063 | Chorionic Gonadotropin |
| ID | Term |
|---|---|
| D006062 | Gonadotropins |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
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| Drug |
Given in different doses and timing to support the luteal phase |
|
| 1 year |
| Ongoing pregnancy rate | Pregnancies ongoing beyond 12 weeks gestation | 1 year |
| Live birth rate | Pregnancies resulting in a live birth | 1 year |
| Adam International hospital |
| Giza |
| Egypt |
| Nile IVF center | Giza | Egypt |
| D010926 | Placental Hormones |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D011257 | Pregnancy Proteins |
| D011506 | Proteins |