Effects of Local Insulin on Wound Angiogenesis

Effects of Local Insulin on Angiogenesis in Acute Wounds in Non-diabetic Patients

Randomized, split plot, double-blind, placebo controlled trial. Half of the wounds surface was applied daily with insulin and the other half with saline solution as placebo. Biopsy specimens of the two sides were obtained on days 0 and 14. Number of blood vessels will be evaluated as main outcome.

Randomized, split plot, double-blind, placebo controlled trial. Non-diabetic patients with full-thickness wounds will be treated in the following manner: in half of the surface insulin will be applied in a daily basis, on the other half, saline solution will be used as placebo. Biopsy specimens of both sides will be obtained on days 0 and 14. Number of blood vessels will be evaluated as main outcome.

Inclusion Criteria:

• Nondiabetic patients with full-thickness acute wounds

Exclusion Criteria:

• Diabetic patients