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Microparticules (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with merging role in pathophysiology of immune and cardiovascular diseases. MPs have been characterized during septic shock and may contribute to dissemination of pro-inflammatory and procoagulant mediators. This a prospective observational study of circulating MPs and blood coagulation in septic shock patients admitted in medical intensive care units (ICUs) of four tertiary hospitals at baseline (D1, D2, D3, D4, D7).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patients | patients with septic shock | ||
| control | patients without septic shock | ||
| healthy volunteers |
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| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in number and type of circulating microparticles at 7 days | Baseline and 7 days | |
| Change from baseline in blood coagulation markers at 7 days | Baseline and 7 days |
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Inclusion Criteria:
Exclusion Criteria:
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group patient: patients with septic shock group control: patients without septic shock
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ferhat MEZIANI, MD, PhD | Contact | ferhat.meziani@chru-strasbourg.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nouvel Hopital Civil | Recruiting | Strasbourg | Alsace | 67091 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32651674 | Derived | Helms J, Severac F, Merdji H, Clere-Jehl R, Francois B, Mercier E, Quenot JP, Meziani F; CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sepsis). Performances of disseminated intravascular coagulation scoring systems in septic shock patients. Ann Intensive Care. 2020 Jul 10;10(1):92. doi: 10.1186/s13613-020-00704-5. |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| D012772 | Shock, Septic |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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blood
| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |